Abstract: 【Abstract】 Objective To investigate the prevalence and clinical characteristics of pruritus in adult patients with psoriasis vulgaris, and to evaluate the effect of pruritus on sleep and quality of life. Methods From January 2020 to December 2020, 291 patients with psoriasis vulgaris were enrolled in Lanzhou University Second Hospital, and characteristics of pruritus as well as quality of sleep and life were evaluated by physicians directly or through a questionnaire. Binary logistic regression analysis was performed to analyze risk factors for pruritus, and multivariate linear regression to analyze related factors affecting sleep and quality of life. Results Among the 291 patients with psoriasis vulgaris, 184 （63.23%） were males and 107 （36.77%） were females, with the age （M ［Q1, Q3］） being 37.00 （28.00, 50.00） years; 258（88.64%） had the itching symptom, and the severity of itching was usually moderate. The severity of skin lesions was the main risk factor for pruritus （OR = 1.252, 95% CI: 1.114－1.407, P < 0.001）. Psoriasis area and severity index was positively correlated with pruritus numerical rating scale （NRS） score （r = 0.65, P < 0.001）, 5-D′S score （r =0.65, P < 0.001）, Pittsburgh sleep quality index （PSQI） score （r = 0.48, P < 0.001） and dermatology life quality index （DLQI） score （r = 0.63, P < 0.001）, the pruritus NRS score was positively correlated with the DLQI score （r = 0.61, P < 0.001） and PSQI score （r = 0.55, P < 0.001）, and the 5-D′S score was positively correlated with the DLQI score （r = 0.62, P < 0.001） and PSQI score （r = 0.64, P < 0.001）. Conclusion Most adult patients with psoriasis vulgaris have moderate pruritus; the severity of disease markedly affects the severity of pruritus, and pruritus exerts a major impact on sleep and quality of life.

Key words: Psoriasis, Pruritus, Quality of life, Sleep, Root cause analysis, Questionnaires