日光光动力疗法在光线性角化病的临床应用进展

doi:10.35541/cjd.20191117

Abstract

Abstract: 【Abstract】 Actinic keratosis （AK） is a kind of precancerous skin lesions related to long-term light exposure, and photodynamic therapy is one of its main treatment methods. Compared with conventional photodynamic therapy （C-PDT）, daylight photodynamic therapy （DL-PDT） with daylight as a light source has advantages of more convenient operation, less pain and higher patient acceptability, but it is liable to be affected by weather and other factors. DL-PDT is suitable for the treatment of grade Ⅰ or Ⅱ AK on the head and face, and its efficacy may be affected by pretreatment, photosensitizers, irradiation dose, etc. This review mainly elaborates the advantages of DL-PDT and introduces its operation methods to help clinicians choose the best treatment protocol for AK.

Key words: Keratosis, actinic, Photochemotherapy, Heliotherapy, Treatment outcome, Root cause analysis

Jin Shuang, Huang Dan, Chen Kun. Daylight photodynamic therapy for the treatment of actinic keratosis[J]. Chinese Journal of Dermatology, 2021, 54(11): 1023-1027.doi:10.35541/cjd.20191117

References ［31］

［1］	Olsen EA, Abernethy ML, Kulp⁃Shorten C, et al. A double⁃blind, vehicle⁃controlled study evaluating masoprocol cream in the treatment of actinic keratoses on the head and neck［J］. J Am Acad Dermatol, 1991,24（5 Pt 1）:738⁃743. doi: 10.1016/0190⁃9622（91）70113⁃g.
［2］	Ibbotson S, Stones R, Bowling J, et al. A consensus on the use of daylight photodynamic therapy in the UK［J］. J Dermatolog Treat, 2017,28（4）:360⁃367. doi: 10.1080/09546634.2016.1240863.
［3］	Werner RN, Stockfleth E, Connolly SM, et al. Evidence⁃ and consensus⁃based （S3） guidelines for the treatment of actinic keratosis ⁃ International League of Dermatological Societies in cooperation with the European Dermatology Forum ⁃ short version［J］. J Eur Acad Dermatol Venereol, 2015,29（11）:2069⁃2079. doi: 10.1111/jdv.13180.
［4］	Nguyen M, Sandhu SS, Sivamani RK. Clinical utility of daylight photodynamic therapy in the treatment of actinic keratosis ⁃ a review of the literature［J］. Clin Cosmet Investig Dermatol, 2019,12:427⁃435. doi: 10.2147/CCID.S167498.
［5］	Ang JM, Riaz IB, Kamal MU, et al. Photodynamic therapy and pain: a systematic review［J］. Photodiagnosis Photodyn Ther, 2017,19:308⁃344. doi: 10.1016/j.pdpdt.2017.07.002.
［6］	Sotiriou E, Evangelou G, Papadavid E, et al. Conventional vs. daylight photodynamic therapy for patients with actinic keratosis on face and scalp: 12⁃month follow⁃up results of a randomized, intra⁃individual comparative analysis［J］. J Eur Acad Dermatol Venereol, 2018,32（4）:595⁃600. doi: 10.1111/jdv.14613.
［7］	Fargnoli MC, Piccioni A, Neri L, et al. Conventional vs. daylight methyl aminolevulinate photodynamic therapy for actinic keratosis of the face and scalp: an intra⁃patient, prospective, comparison study in Italy［J］. J Eur Acad Dermatol Venereol, 2015,29（10）:1926⁃1932. doi: 10.1111/jdv.13076.
［8］	Zhu L, Wang P, Zhang G, et al. Conventional versus daylight photodynamic therapy for actinic keratosis: a randomized and prospective study in China［J］. Photodiagnosis Photodyn Ther, 2018,24:366⁃371. doi: 10.1016/j.pdpdt.2018.10.010.
［9］	Lacour JP, Ulrich C, Gilaberte Y, et al. Daylight photodynamic therapy with methyl aminolevulinate cream is effective and nearly painless in treating actinic keratoses: a randomised, investigator⁃blinded, controlled, phase III study throughout Europe［J］. J Eur Acad Dermatol Venereol, 2015,29（12）:2342⁃2348. doi: 10.1111/jdv.13228.
［10］	Rubel DM, Spelman L, Murrell DF, et al. Daylight photodynamic therapy with methyl aminolevulinate cream as a convenient, similarly effective, nearly painless alternative to conventional photodynamic therapy in actinic keratosis treatment: a randomized controlled trial［J］. Br J Dermatol, 2014,171（5）:1164⁃1171. doi: 10.1111/bjd.13138.
［11］	See JA, Gebauer K, Wu JK, et al. High patient satisfaction with daylight⁃activated methyl aminolevulinate cream in the treatment of multiple actinic keratoses: results of an observational study in Australia［J］. Dermatol Ther （Heidelb）, 2017,7（4）:525⁃533. doi: 10.1007/s13555⁃017⁃0199⁃9.
［12］	Calzavara⁃Pinton P, Zane C, Arisi M, et al. Evaluation of the costs of topical treatments for actinic keratosis based on lesion response and the affected area［J］. G Ital Dermatol Venereol, 2018,153（6）:764⁃775. doi: 10.23736/S0392⁃0488.18.06071⁃6.
［13］	Philipp⁃Dormston WG, Sanclemente G, Torezan L, et al. Daylight photodynamic therapy with MAL cream for large⁃scale photodamaged skin based on the concept of ′actinic field damage′: recommendations of an international expert group［J］. J Eur Acad Dermatol Venereol, 2016,30（1）:8⁃15. doi: 10.1111/jdv.13327.
［14］	See JA, Shumack S, Murrell DF, et al. Consensus recommendations on the use of daylight photodynamic therapy with methyl aminolevulinate cream for actinic keratoses in Australia［J］. Australas J Dermatol, 2016,57（3）:167⁃174. doi: 10.1111/ajd.12354.
［15］	Morton CA, Wulf HC, Szeimies RM, et al. Practical approach to the use of daylight photodynamic therapy with topical methyl aminolevulinate for actinic keratosis: a European consensus［J］. J Eur Acad Dermatol Venereol, 2015,29（9）:1718⁃1723. doi: 10.1111/jdv.12974.
［16］	Wenande E, Phothong W, Bay C, et al. Efficacy and safety of daylight photodynamic therapy after tailored pretreatment with ablative fractional laser or microdermabrasion: a randomized, side⁃by⁃side, single⁃blind trial in patients with actinic keratosis and large⁃area field cancerization［J］. Br J Dermatol, 2019,180（4）:756⁃764. doi: 10.1111/bjd.17096.
［17］	Nissen CV, Heerfordt IM, Wiegell SR, et al. Pretreatment with 5⁃fluorouracil cream enhances the efficacy of daylight⁃mediated photodynamic therapy for actinic keratosis［J］. Acta Derm Venereol, 2017,97（5）:617⁃621. doi: 10.2340/00015555⁃2612.
［18］	Galimberti GN. Calcipotriol as pretreatment prior to daylight⁃mediated photodynamic therapy in patients with actinic keratosis: a case series［J］. Photodiagnosis Photodyn Ther, 2018,21:172⁃175. doi: 10.1016/j.pdpdt.2017.11.019.
［19］	Osman⁃Ponchet H, Sevin K, Gaborit A, et al. Lack of effect of selected sunscreens applied on ex vivo human skin for 5⁃methyl⁃aminolevulinic acid penetration and protoporphyrin IX photoactivation［J］. Photodiagnosis Photodyn Ther, 2017,17:75⁃81. doi: 10.1016/j.pdpdt.2016.11.012.
［20］	Ozog DM, Rkein AM, Fabi SG, et al. Photodynamic therapy: a clinical consensus guide［J］. Dermatol Surg, 2016,42（7）:804⁃827. doi: 10.1097/DSS.0000000000000800.
［21］	Räsänen JE, Neittaanmäki N, Ylitalo L, et al. 5⁃Aminolaevulinic acid nanoemulsion is more effective than methyl⁃5⁃aminolaevulinate in daylight photodynamic therapy for actinic keratosis: a nonsponsored randomized double⁃blind multicentre trial［J］. Br J Dermatol, 2019,181（2）:265⁃274. doi: 10.1111/bjd.17311.
［22］	Neittaanmäki⁃Perttu N, Karppinen TT, Tani T, et al. Long⁃term outcome of low⁃concentration hexyl⁃5⁃aminolaevulinate daylight photodynamic therapy for treatment of actinic keratoses［J］. Acta Derm Venereol, 2017,97（1）:120⁃121. doi: 10.2340/00015555⁃2484.
［23］	Vignion⁃Dewalle AS, Baert G, Thecua E, et al. Comparison of 10 efficient protocols for photodynamic therapy of actinic keratosis: how relevant are effective light dose and local damage in predicting the complete response rate at 3 months?［J］. Lasers Surg Med, 2018,50（5）:576⁃589. doi: 10.1002/lsm.22827.
［24］	Wiegell SR, Haedersdal M, Philipsen PA, et al. Continuous activation of PpIX by daylight is as effective as and less painful than conventional photodynamic therapy for actinic keratoses; a randomized, controlled, single⁃blinded study［J］. Br J Dermatol, 2008,158（4）:740⁃746. doi: 10.1111/j.1365⁃2133.2008.08450.x.
［25］	Wiegell SR, Fabricius S, Stender IM, et al. A randomized, multicentre study of directed daylight exposure times of 1[12] vs. 2[12] h in daylight⁃mediated photodynamic therapy with methyl aminolaevulinate in patients with multiple thin actinic keratoses of the face and scalp［J］. Br J Dermatol, 2011,164（5）:1083⁃1090. doi: 10.1111/j.1365⁃2133.2011.10209.x.
［26］	Wiegell SR, Fabricius S, Heydenreich J, et al. Weather conditions and daylight⁃mediated photodynamic therapy: protoporphyrin IX⁃weighted daylight doses measured in six geographical locations［J］. Br J Dermatol, 2013,168（1）:186⁃191. doi: 10.1111/j.1365⁃2133.2012.11200.x.
［27］	O′Mahoney P, Khazova M, Eadie E, et al. Measuring daylight: a review of dosimetry in daylight photodynamic therapy［J］. Pharmaceuticals （Basel）, 2019,12（4）:143. doi: 10.3390/ph1204 0143.
［28］	O′Gorman SM, Clowry J, Manley M, et al. Artificial white light vs daylight photodynamic therapy for actinic keratoses: a randomized clinical trial［J］. JAMA Dermatol, 2016,152（6）:638⁃644. doi: 10.1001/jamadermatol.2015.5436.
［29］	Gutiérrez García⁃Rodrigo C, Pellegrini C, Piccioni A, et al. Single versus two⁃treatment schedule of methyl aminolevulinate daylight photodynamic therapy for actinic keratosis of the face and scalp: an intra⁃patient randomized trial［J］. Photodiagnosis Photodyn Ther, 2019,27:100⁃104. doi: 10.1016/j.pdpdt.2019.05. 031.
［30］	Gracia⁃Cazaña T, Malinis A, Almagro⁃Sánchez M, et al. Sequential daylight photodynamic therapy and ingenol mebutate versus 2 sessions of daylight photodynamic therapy for the treatment of actinic keratosis: an observational, prospective, comparative study［J］. Photodiagnosis Photodyn Ther, 2019,27:34⁃38. doi: 10.1016/j.pdpdt.2019.05.030.
［31］	Karrer S, Aschoff R, Dominicus R, et al. Methyl aminolevulinate daylight photodynamic therapy applied at home for non⁃hyperkeratotic actinic keratosis of the face or scalp: an open, interventional study conducted in Germany［J］. J Eur Acad Dermatol Venereol, 2019,33（4）:661⁃666. doi: 10.1111/jdv.15422.

[1]	Song Yuqing, Yang Nan, Liu Linlin, Feng Ziyi, Han Shixin, Zhou Meijuan. Dermabrasion for the treatment of familial benign chronic pemphigus: a clinical observation of 6 cases [J]. Chinese Journal of Dermatology, 2024, 0(4): 20220278-e20220278.
[2]	Ge Xinhong, Ma Yingdong, Jiao Yaning, Liu Lingling, Zhou Mei, Zi Wei, Li Bowen. Analysis of efficacy and safety of 532-nm picosecond laser in the treatment of early-stage facial seborrheic keratosis [J]. Chinese Journal of Dermatology, 2024, 57(4): 359-362.
[3]	Liu Yi, Qu Ying, Lei Wenzhi, Liu Xiaogang, Pan Weihua, Zhang Chao. Clinical efficacy of salt-packing therapy in the treatment of pyogenic granuloma [J]. Chinese Journal of Dermatology, 2024, 0(4): 20230553-e20230553.
[4]	Zhang Dimin, Cao Cheng, Zhou Miaoni, Sheng Anqi, Lin Fuquan, Xu Ai′e. Analysis of disease control rate and its influencing factors in patients with progressive non-segmental vitiligo after combined treatment with compound betamethasone injection [J]. Chinese Journal of Dermatology, 2024, 57(4): 350-354.
[5]	Tian Jing, Deng Sisi, Song Zhiqiang . A comparison of clinical characteristics between atopic and non-atopic prurigo nodularis [J]. Chinese Journal of Dermatology, 2024, 57(4): 331-337.
[6]	Zhang Qian, Zhang Jin′e, Guo Sen, Song Pu, Gao Lin, Li Chunying. Comparison of the efficacy of fractional CO2 laser combined with topical delivery of fluorouracil versus compound betamethasone injections in the treatment of vitiligo: a clinical observation [J]. Chinese Journal of Dermatology, 2024, 57(1): 34-38.
[7]	Liu Yuanxiang, Liang Yuan, Zhao Xinrong, Sun Yujuan, Ma Lin, Xu Zigang. Janus kinase inhibitors for the treatment of five children with severe alopecia areata [J]. Chinese Journal of Dermatology, 2023, 56(9): 849-852.
[8]	Zhong Jiemin, Shao Lei, Liang Yimin, Huang Qiongxiao, Xia Manqi, Liu Yumei. Comparative study on efficacy and safety of single microneedle radiofrequency versus photodynamic therapy in the treatment of inflammatory lesions of moderate to severe facial acne vulgaris [J]. Chinese Journal of Dermatology, 2023, 56(8): 751-755.
[9]	Wang Junxia, Guo Weinan, Chen Hui, Hao Junfeng, Li Bing, Wei Jingyi, Zhao Tao. Efficacy of autologous fat grafting in the treatment of 40 cases of stable linear scleroderma: a retrospective analysis [J]. Chinese Journal of Dermatology, 2023, 56(8): 762-765.
[10]	Yang Nali, Xu Qiuyang, Wu Hanwen, Ye Yahui, Zhu Jiling, Liu Jingjing, Li Zhiming. Efficacy and safety of omalizumab in the treatment of chronic urticaria: a retrospective analysis [J]. Chinese Journal of Dermatology, 2023, 56(6): 518-524.
[11]	Su Chang, Sui Xiuli, Liu Ruiling, Cao Yiqun, Jiang Hong, Yan Cairong, Wang Huiping, Qi Yuqing. Omalizumab for the treatment of 74 patients with chronic spontaneous urticaria accompanied by other allergic diseases: a clinical analysis [J]. Chinese Journal of Dermatology, 2023, 56(6): 512-517.
[12]	Wang Xin, Liu Lijuan, Li Linfeng. Clinical features of chronic spontaneous urticaria in China: results from a hospital-based multicenter epidemiological survey [J]. Chinese Journal of Dermatology, 2023, 56(6): 525-530.
[13]	Li Liqiao, Peng Cong, Chen Xiang, Li Jie. Efficacy of omalizumab in the treatment of chronic urticaria patients with poor response to antihistamines: a single-center retrospective study [J]. Chinese Journal of Dermatology, 2023, 56(6): 504-511.
[14]	Li Rong, Zhang Jiaan, Chen Kun. Photoelectric therapy for rosacea [J]. Chinese Journal of Dermatology, 2023, 56(5): 468-470.
[15]	Guo Weinan, Wang Junxia, Chen Hui, Hao Junfeng, Li Bing, Wei Jingyi, Zhao Tao. Clinical efficacy of autologous adipose-derived stem cell gel grafting in the treatment of depressed acne scars [J]. Chinese Journal of Dermatology, 2023, 0(3): 20210867-e20210867.

Daylight photodynamic therapy for the treatment of actinic keratosis

PDF

PDF (Mobile)

Knowledge

Abstract

Cite this article

share this article

References ［31］

Related Articles 15

Metrics

Comments

Recommended 10