Chinese Journal of Dermatology ›› 2020, Vol. 53 ›› Issue (5): 390-394.doi: 10.35541/cjd.20190430

• Reviews • Previous Articles     Next Articles

Role of interleukin-17A in the occurrence and treatment of psoriasis

Zhu Guannan, Wang Gang   

  1. Department of Dermatology, Xijing Hospital, The Fourth Military Medical University, Xi′an 710032, China
  • Received:2019-03-26 Revised:2019-09-21 Online:2020-05-15 Published:2020-04-30
  • Contact: Wang Gang
  • Supported by:
    Key Research and Development Program of Shaanxi Province of China (2018SF-334)

Abstract: 【Abstract】 In the last 10 years, emerging evidence from basic researches and clinical trials have revealed and confirmed a critical role of Th17/interleukin-17A (IL-17A) in the occurrence of psoriasis. Besides affecting the proliferative activity and functions of keratinocytes, IL-17A also plays an important role in the regulation of immune cells and related cytokines in the immune microenvironment in psoriasis. In recent years, monoclo20190138nal antibodies targeting the IL-17A pathway, such as Secukinumab, Ixekizumab and Brodalumab, have been successively marketed in China and other countries, and have exhibited marked efficacy in clinical practice. This review summarizes latest advances in the role of IL-17A in the pathogenesis of psoriasis as well as in biotherapies targeting IL-17A and its receptor IL-17RA.

Key words: Psoriasis, Th17 cells, Antibodies, monoclonal, Interleukin-17A