Chinese Journal of Dermatology ›› 2025, Vol. 58 ›› Issue (9): 868-872.doi: 10.35541/cjd.20250078

• Reviews • Previous Articles     Next Articles

Pathogenesis and treatment of melasma

Jiang Ziqi1, Zhong Judan1, Chen Tingqiao2, Chen Jin1   

  1. 1Department of Dermatology, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China; 2Department of Dermatology and Medical Aesthetics, Women and Children's Hospital of Chongqing Medical University, Chongqing 401120, China
  • Received:2025-02-18 Revised:2025-08-07 Online:2025-09-15 Published:2025-09-01
  • Contact: Chen Jin E-mail:chenjin7791@163.com
  • Supported by:
    National Natural Science Foundation of China (82404174); Natural Science Foundation of Chongqing (CSTB2023NSCQ-MSX0075);  Chongqing Talent Plan Project (cstc2024ycjh-bgzxm0177); Qian De Science and Technology Talent Project of the First Affiliated Hospital of Chongqing Medical University (2025QDTS-11)

Abstract: 【Abstract】 Melasma is an acquired pigmentation disorder with complex pathogenesis. In addition to the dysfunction of melanocytes, the imbalance of the microenvironment, particularly the multicellular interactions among keratinocytes, fibroblasts, vascular endothelial cells, mast cells, and sebocytes, also contributes to the progression of melasma. This review summarizes relevant research progress on melanocytes and their microenvironment in the pathogenesis of melasma, as well as advances in the treatment of melasma.

Key words: Melasma, Melanocytes, Pathogenesis, Therapy, Microenvironment