Chinese Journal of Dermatology ›› 2025, Vol. 58 ›› Issue (7): 591-594.doi: 10.35541/cjd.20240545

• Commentary • Previous Articles     Next Articles

Androgenetic alopecia and metabolic syndrome: from mechanisms to treatment strategies

Lin Jinran, Leong Hiochon, Liu Qingmei, Wu Wenyu   

  1. Lin Jinran, Leong Hiochon, Liu Qingmei, Wu Wenyu
  • Received:2024-10-12 Revised:2025-05-12 Online:2025-07-15 Published:2025-07-03
  • Contact: Wu Wenyu E-mail:wenyu_wu@fudan.edu.cn
  • Supported by:
    Shanghai Natural Science Foundation(24ZR1408300); Leading Talent Project of Shanghai Health Commission (2022LJ017); Clinical Research Plan of Shanghai Hospital Development Center Foundation (SHDC22022302); Shanghai Engineering Research Center of Hair Medicine (19DZ2250500); Key Specialty Research Centre of Shanghai Health Commission (2023ZZ02018); Shanghai Municipal Key Clinical Specialty (shslczdzk01002)

Abstract: 【Abstract】 Androgenetic alopecia (AGA) is the most common type of hair loss in humans, characterized by the patterned miniaturization of scalp hair follicles and shortened anagen phases. Recent studies have revealed a significant association between AGA and metabolic syndrome (MetS). The hallmarks of MetS include abdominal obesity, impaired glucose metabolism, hypertension, and dyslipidemia. This commentary evaluates the epidemiological association between AGA and MetS, explores the underlying concurrent mechanisms, and discusses current and potential therapeutic strategies.

Key words: Alopecia, Androgenetic alopecia, Metabolic syndrome, Insulin resistance, Pathogenesis, Therapy