Abstract: 【Abstract】 Persistent centrofacial erythema with transient flushing is the most common clinical manifestation of rosacea. However, its pathological mechanisms are poorly understood, and there is a lack of high-level evidence from clinical studies. Based on research progress and clinical experience in China and other countries, the authors emphasize the necessity that facial flushing with erythema should be investigated as an independent clinical phenotype during the study. It is believed that mental stress, anxiety and/or depression may be driving factors in the pathogenesis of facial flushing with erythema. Based on mental factors, it is of potential clinical significance to investigate the relationship of neuroinflammation involved in facial flushing and erythema with skin immunity and blood vessels in rosacea.

Key words: Rosacea, Flushing, Erythema, Anxiety, Mental stress, Neuroinflammation