Chinese Journal of Dermatology ›› 2010, Vol. 43 ›› Issue (9): 649-650.

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Expression of PI3K-Akt in the tissue of cutaneous squamous cell carcinoma

  

  • Received:2010-01-04 Revised:2010-02-06 Online:2010-09-15 Published:2010-09-10

Abstract:

Abstract: Objective To detect the expression of PI3K and AKT in cutaneous squamous cell carcinoma (SCC) tissue. Methods The expressions of PI3K and AKT were detected in 41 cases of SCC tissue and 11 cases of normal skin tissue by immunohistochemical SP. Results The positive expression rates of PI3K and AKT in SCC were higher than those in normal skin tissue ( P <0. 05). The expression of PI3K in SCC tissue was postively correlated with that of AKT (r = 0. 418, P <0. 05). Conclusion It is suggested that expression of PI3K and AKT may be closely correlated with generation of SCC.

Key words: cutaneous neop lasm, squamous cell carcinoma, PI3K, AKT