Abstract: Objective To evaluate the efficacy and safety of 5% imiquimod cream in the treatment of condyloma acuminatum.Methods The PubMed,Ovid,Web of Science,UMI,Elsevier,Cochrane Library,CNKI and CBMDisc were searched.The randomized controlled trials (RCT) comparing 5% imiquimod cream versus placebo or fluorouracil cream were included,and two authors independently reviewed the data and assessed the quality.The data were inputted and analyzed by RevMan 4.2.8 software supplied by the Cochrane Collaboration.Results Eight trials ranked high quality were included.Meta-analysis of the treatment of condyloma acuminatum with 5% imiquimod cream showed the clinical effective rates were significantly different between 5% imiquimod cream and placebo,while were not between 5% imiquimod and flurouracil cream.No serious systematical adverse reaction was recorded.Conclusion Topical 5% imiquimod cream is an effective and safe regimen for the treatment of condyloma acuminatum.

Key words: Condylomata acuminata, Randomized controlled trials, Meta-analysis, Imiquimod