Abstract: Huang Dan, Ju Mei, Chang Baozhu, Chen Xu, Zhang Xiaohua, Zhu Yan, Zhou Ya′nan, Xu Nan, Chen Kun, Gu Heng Department of Physical Therapy, Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs, Nanjing 210042, China Corresponding authors: Chen Kun, Email: kunchen181@aliyun.com; Gu Heng, Email: doctor_guheng@hotmail.com 【Abstract】 Objective To analyze clinical features and treatment outcomes of female children with condyloma acuminatum. Methods Female outpatients with condyloma acuminatum aged less than 12 years were enrolled into this study. Through a questionnaire survey, medical histories were collected, and a physical examination was performed in these patients. Polymerase chain reaction （PCR） was conducted to determine the genotypes of human papillomavirus （HPV）. Descriptive statistical methods were used to identify high risk factors for condyloma acuminatum, manifestations of skin lesions, and results of HPV test. The number of sessions of laser therapy and photodynamic therapy was also recorded. Results A total of 51 female children aged under 12 years with a diagnosis of condyloma acuminatum were enrolled into this study. Their median age and course of disease （M ［P25 - P75］） were 3 （2 - 5） years and 6 （4 - 8） months respectively. Of the 51 patients, 29（56.9%） lived in the small towns or suburb of a city, and 16 （31.4%） lived in the rural areas. Only 2 children′s parents had a definite HPV infection history. Twelve children （23.6%） usually wore open-seat pants, 24 （47%） often took a bath in public bath houses, and only 1 child had a definite history of sexual assault. Among these patients, 39 （76.5%） mainly had perianal skin lesions, and all cauliflower-like lesions occurred on the perianal area. A total of 35 patients underwent the HPV test in the exfoliated cells. The positive rate of HPV was 71.4%, and all the HPV-positive patients were infected by low-risk HPV types （HPV6/11）. During the treatment, 5 patients were lost to follow-up. In the remaining 46 patients, the median number of sessions of laser therapy and photodynamic therapy was 2 （1 - 4） and 3 （3 - 4）respectively. The median course of treatment was 4 （2 - 6）months. After the treatment, all the remaining 46 patients were cured with a recovery rate of 90.2%（46/51）. Conclusions In these female children with condyloma acuminatum, the source of infection may maninly come from the environment, and skin lesions mostly occur on the perianal area. The prognosis is good after laser and photodynamic therapy.

Key words: Condylomata acuminata, Child, Skin manifestations, Treatment outcome