Abstract: 【Abstract】 Objective To evaluate the efficacy and safety of 585 nm pulsed dye laser for the treatment of molluscum contagiosum in children. Methods Between September 2016 and February 2017, 50 children with confirmed molluscum contagiosum were enrolled from Maternal and Child Health Care Hospital of Zibo. These children were treated with 585 nm pulsed dye laser at energy of 6.0 - 9.0 J/cm2, pulse width of 0.5 ms and spot size of 5 mm. If a patient was not cured after 1 session of the laser treatment, another session of the laser treatment would be performed 1 month after the first treatment. If the proportion of regressed skin lesions was less than 30% after more than 2 consecutive sessions of the laser treatment, the treatment would be stopped. After the treatment, the patients were followed up for 6 months. During the follow-up, clinical efficacy was evaluated according to regression of skin lesions, and adverse reactions and recurrence were recorded. Results All the patients completed the trial. After the treatment, 44 （88%） patients were cured, and the response rate was 94% （47/50）. After 1 session of the treatment, 32 （64%） patients were cured. After the laser treatment, purpura occurred instantly, hyperpigmentation and hypopigmentation occurred in a short-term period, and no obvious long-term adverse reactions were observed. During the follow-up, no new wart was found at the site of regressed warts after the treatment. Conclusion The 585 nm pulsed dye laser shows good efficacy, safety and tolerance in the treatment of molluscum contagiosum.

Key words: Lasers, dye, Treatment outcome, Adverse reactions, Molluscum contagiosum