Abstract: Objective To report the surgical approach for the treatment of giant or extensive skin lesions due to the infection of human papilloma virus (HPV).Method Surgical treatment was performed for 10 patients with verruca vulgris,20 with condyloma acuminatum,and 8 with epidermodyplasia verruciformis,whose giant or extensive lesions were poorly responsive to routine non-surgical therapy.Results Recurrence of lesions was found in 2 of 10 patients with verruca vulgris and 5 of 20 condyloma acuminatum in 6 months after operation,with a total recurrent rate of 25%.The extensive skin lesions were removed and the functions of affected limbs were recovered in patients with epidermodyplasia verruciformis after operation,however,the long-term topical retinoids was needed to control the recurrence of the lesions.Conclusion Surgical approach is effective for the treatment of the giant or extensive skin lesions due to HPV infection.

Key words: Warts, Surgical procedure, operative