Chinese Journal of Dermatology ›› 2005, Vol. 38 ›› Issue (3): 148-150.

• Original articles • Previous Articles     Next Articles

Serum Levels of Hepatocyte Growth Factor and Granulocyte Macrophage-Colony Stimulating Factor in Patients with Psoriasis

XU Bing1, WANG Yong-gang1, WU Wei2, WU Ling-jiao2   

  1. Department of Dermatology, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China
  • Received:2004-01-07 Online:2005-03-15 Published:2005-03-15

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Abstract: Objective To investigate the serum levels of hepatocyte growth factor (HGF) and granulocyte macrophage-colony stimulating factor (GM-CSF) in patients with psoriasis.Methods Serum samples were collected from 68 patients with psoriasis vulgaris and 42 healthy controls.The serum concentrations of HGF and GM-CSF were measured by a dual antibody sandwich enzyme-linked immunosorbent assay (ELISA).Clinical severity of psoriasis vulgaris was assessed by psoriasis area and severity index (PASI) score.Results Serum concentration of HGF of patients with psoriasis vulgaris in progressive stage (653.35±109.26 pg/mL) was significantly higher than that of the normal controls (353.85±162.63 pg/mL) (P<0.01),and of the patients in stable stage (362.35±120.40 pg/mL) (P<0.01).The serum concentration of HGF between the patients in stable stage and normal controls was not significantly different (P>0.05).The serum concentration of GM-CSF was significantly higher in the patients with psoriasis vulgaris of progressive stage (115.95±25.72 pg/mL) than that in the patients of stable stage (68.28±24.22 pg/mL) (P<0.01),and in healthy controls (53.11±25.92 pg/mL) (P<0.01).And serum concentration of GM-CSF was significantly increased in the patients of stable stage compared with normal controls (P<0.05).Between the progressive stage patients with generalized lesions and those with localized lesions,no significant differences were observed in serum HGF,and GM-CSF.There were significant correlations between PASI score with serum concentration of HGF,and with that of GM-CSF (r=0.38 and r=0.30,P<0.002 and P<0.02,respectively).Conclusions The Results indicate that serum concentrations of HGF and GM-CSF are significantly increased in the patients with psoriasis vulgaris,and that serum concentrations of HGF and GM-CSF correlate significantly with the activity and severity of psoriasis.These data suggest that HGF and GM-CSF may be involved in the pathogenesis of psoriasis.

Key words: Psoriasis, Hepatocyte growth factor, Granulocyte-macrophage-colony-stimulating factor