Chinese Journal of Dermatology ›› 2005, Vol. 38 ›› Issue (3): 146-147.

• Original articles • Previous Articles     Next Articles

Expression of Pituitary Adenylate Cyclase Activating Polypeptide and its Receptor in Psoriatic Lesions and Non-lesional Skins

ZHANG Li-jun1, YANG Xue-qin2, MENG Ru-song2, LI You2, JIANG Li2   

  1. Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi'an 710033, China
  • Received:2003-10-30 Online:2005-03-15 Published:2005-03-15

PDF

98

Like

Abstract: Objective To investigate the effects of pituitary adenylate cyclase activating polypeptide (PACAP) and its receptor (PACAP-R) on the pathogenesis of psoriasis.Methods The expression of PACAP and PACAP-R in the skin from 10 normal controls,25 psoriatic lesions and non-lesional skins was measured by immunohistochemical technique.Results The expression of PACAP and PACAP-R was significantly lower in the psoriatic lesional skins than that of the non-lesional skins.The area density and mean absorbance of PACAP and PACAP-R in the lesional skins were significantly lower compared with those in the non-lesional skins (P<0.01).The area density and mean absorbance of PACAP and PACAP-R in the non-lesional skins were significantly lower compared with those in the normal controls (P<0.05).Conclusions The down-expression of PACAP and PACAP-R in psoriatic skin suggests that PACAP might be related to the hyperproliferation of psoriatic keratinocytes.

Key words: Psoriasis, Pituitary adenylate cyclase activating polypeptide