Abstract: Objectives To investigate the association between HLA-DQB1 alleles and Han Chinese with generalized pustular psoriasis (GPP) from Shandong.Methods The distributing frequencies of HLA-DQB1 alleles were detected with polymerase chain reaction-sequence specific primers (PCR-SSP) in 38 GPP patients and 94 healthy subjects from Shandong.Results ①The frequencies of HLA-DQB1*0201 and *0603 alleles increased significantly in GPP patients compared with those of the healthy controls(Pc=0.005 and Pc=0.013,respectively),and the frequency of HLA-DQB1*0604 alleles decreased (OR=0.08,Pc=0.039).②There were significant association between the GPP patients with a previous history of psoriasis vulgaris and HLA-DQB1*0201 and *0603 alleles (OR=32.31,Pc=0.005;OR=12.42,Pc=0.005,respectively),and between the GPP patients without the history and HLA-DQB1*0602 alleles (OR=5.60,Pc=0.039).Conclusions HLA-DQB1*0201 and *0603 alleles are significantly associated with the Chinese patients with GPP in Han population from Shandong.There is a significant heterogeneity in the GPP patients with and without the history of psoriasis vulgaris.

Key words: Psoriasis, Genes,MHC classⅡ