Chinese Journal of Dermatology ›› 1999, Vol. 32 ›› Issue (2): 99-100.

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Study on Pathogenesis of Guttate Type Psoriasis Induced by Group A β-haemolytic Streptococcal Infection

ZHANG Litao1, CHEN Xuerong1, YIN Jinzhu2   

  1. Department of Dermatology, The Third School of Clinical Medicine, Beijing Medical University, Beijing 100083
  • Received:1997-12-01 Revised:1998-08-07 Online:1999-04-15 Published:1999-04-15

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Abstract: Objective To investigate the pathogenesis of acuteguttate type psoriasis(AGP) in duced by streptococcal infection. Methods The proliferative responses of peripheral blood mononuclear cells (PBMCs) to streptococcal antigens were detected by using MTT methods.Effects of supernatants of PBMCs cultured with streptococcal antigens on DNA synthesis of keratinocytes were measured by 3H-TdR incorporation assay,and immunohistochemical staining was used to examine HLA-DR and intercellular adhesion molecule 1(ICAM 1) expression on keratinocytes. Results The proliferative responses of PBMCs to streptococcal antigens were greatly enhanced in patients with AGP than those in controls (P<0.01).The supernatants of PBMCs in patients with AGP stimulated by streptococcalantigens could significantly increase 3H-TdR incorporation with keratinocytes(P<0.01).And these supernatants from patients with AGP could also induce the expression of HLA-DR and ICAM-1 in human keratinocytes. Conclusion There might be streptococcal antigen-specific T lymphocytes in AGP patients.

Key words: Psoriasis, Streptococcus