蛋白激酶Cζ在银屑病发病中的意义

Abstract

Abstract: Objective To investigate the effects of protein kinase Cζ(PKCζ) on the pathogenesis of psoriasis. Methods The expression and distribution of PKCζwere studied by in situ hybridization and immunohistochemistry in 12 cases of psoriasis. Results The expressions of both PKCζmRNA and the protein were significantly higher in psoriatic epidermis than those in normal epidermis and uninvolved epidermis of psoriatic cases. The expression of PKCζmRNA was located in the upper layers of normal epidermis but the expression was almost in the whole layer in psoriatic epidermis. Conclusion The overexpression of PKCζin psoriatic epidermis suggests that PKCζ might be related to the hyperproliferation of psoriatic keratinocytes.

Key words: Psoriasis, Protein kinase C

ZHANG Xiaoyan, MA Shengqing, LIU Huitu. Significance of Protein Kinase Cζin Pathogenesis of Psoriasis[J].Chinese Journal of Dermatology, 1999, 32(2): 74-76.

[1]	赵斌, 肖生祥, 沈宏, 王俊民. [J]. Chinese Journal of Dermatology, 2005, 38(6): 395 .
[2]	FENG Jing, TU Ya-ting, LING Neng-xing, FENG Ai-ping. Expression of Candida albicans Secreted Aspartyl Proteinase in Acute Vaginal Candidiasis[J]. Chinese Journal of Dermatology, 2005, 38(4): 235 -237 .
[3]	郭志丽, 顾军, 朱海英, 曹云飞, 米庆胜, 肖飞. [J]. Chinese Journal of Dermatology, 2005, 38(1): 53 .
[4]	徐如君, 王宏雁, 吴能定, 金敏, 沈宝珠. [J]. Chinese Journal of Dermatology, 2005, 38(1): 54 .
[5]	LIU Quan-zhong, YAO Wei-feng, QI Man-li, LI Yan, WANG Hui-ping, TIAN Jin-qun. Cloning,expression and identification of chlamydial GPIC capsid Vp1 protein[J]. Chinese Journal of Dermatology, 2006, 39(12): 714 -716 .
[6]	LI Li-hua, HUANG Zhao-hui, GUO Zhi-jian, LIU Zhi-hui, REN Jin-dong, SONG Ming-xu, ZHOU Xi-ke, WANG Fei, BI Zhi-gang. Enhancement of human papillomavirus type 11 DNA vaccine-induced specific immune response by co-immunization with CD80 co-stimulatory gene[J]. Chinese Journal of Dermatology, 2006, 39(12): 717 -719 .
[7]	李福秋, 曲生明, 李若瑜, 王家俊, 刘斌, 赖维, 郑岳臣, 金学洙. [J]. Chinese Journal of Dermatology, 2006, 39(12): 720 -721 .
[8]	朱华江, 唐玲, 苏晓媛, 陈洁. [J]. Chinese Journal of Dermatology, 2006, 39(12): 688 .
[9]	. [J]. Chinese Journal of Dermatology, 2006, 39(4): 235 -237 .
[10]	ZHAO Fei-jun, WU Yi-mou, ZHANG Xiao-hong, LIU Shuang-quan, YANG Sheng-hui, YU Min-jun. Construction of fusion bivalent DNA vaccine of Treponema pallidum and its immune activity[J]. Chinese Journal of Dermatology, 2006, 39(5): 250 -253 .

[1]	Fu Dandan , Hu Hua, Zhang Mengjie, Li Min, Li Zhanguo, Tian Zhongwei. Effect of epigallocatechin gallate on Th1/Th2 immune balance in patients with plaque?type psoriasis [J]. Chinese Journal of Dermatology, 2019, 52(9): 611-615.
[2]	Qin Junxia, Qin Xiaowei, Zhao Peng. T cell immunoglobulin and mucin domain-containing protein 3 inhibits interleukin-12 secretion by CD14+ monocytes from patients with psoriasis vulgaris [J]. Chinese Journal of Dermatology, 2019, 52(9): 598-603.
[3]	Su Beibei, Gan Quan, Gan Caibin. Effects of metformin on inflammatory status and phosphorylated Stat3 expression in lesions of a psoriasis?like mouse model [J]. Chinese Journal of Dermatology, 2019, 52(7): 475-480.
[4]	Chen Yiwen, Su Ting, Su Zhonglan. Association between psoriasis and STAT3 [J]. Chinese Journal of Dermatology, 2019, 52(7): 502-505.
[5]	Qin Hui, Zheng Jie. FTY720 ameliorates psoriasis by inhibiting infiltration of skin Interleukin 17-producing γδT cells [J]. Chinese Journal of Dermatology, 2019, 52(6): 395-400.
[6]	Wang Liwei, Luo Lingling, Cui Pan′gen, Li Min. Relationship between intestinal flora and psoriasis [J]. Chinese Journal of Dermatology, 2019, 52(5): 357-360.
[7]	Hu Yu, Chen Min, Gu Heng. MicroRNA and lncRNA in psoriasis [J]. Chinese Journal of Dermatology, 2019, 52(5): 350-353.
[8]	Pan Jiaxu, Zhou Jing. NF?κB signaling pathway in psoriasis [J]. Chinese Journal of Dermatology, 2019, 52(5): 361-363.
[9]	Zeng Jingxin, Tian Xin, Zhu Huilan, Zhang Xibao, Lin Ling, Zhang Lidan, Liu Weiyu, Luo Quan . Expression of miRNA-148a-3p in CD4⁺ T lymphocytes in peripheral blood of patients with psoriasis vulgaris and its clinical significance [J]. Chinese Journal of Dermatology, 2019, 52(4): 231-235.
[10]	Committee on Psoriasis, Chinese Society of Dermatology. Guideline for the diagnosis and treatment of psoriasis in China （2018 simplified edition） [J]. Chinese Journal of Dermatology, 2019, 52(4): 223-230.
[11]	Working Committee on Standardized Diagnosis and Treatment, China Dermatologist Association, Dermatological Surgical Equipment Group and Skin Phototherapy Group, Committee on Skin Disease and Cosmetic Dermatology, China Association of Medical Equipment. Clinical application of home narrow band ultraviolet B phototherapy: an expert consensus statement [J]. Chinese Journal of Dermatology, 2019, 52(3): 156-161.
[12]	Gao Yimeng, Jin Hongzhong. The role of neuropsychiatric factors in the occurrence of psoriasis [J]. Chinese Journal of Dermatology, 2019, 52(3): 204-207.
[13]	Peng Chen, Chen Wenjuan, Yu Ning, Gao Yunlu, Yi Xuemei, Ding Yangfeng. The progress of relationship between psoriasis and microecology of skin and intestine [J]. Chinese Journal of Dermatology, 2019, 52(2): 135-137.
[14]	Hu Yu, Luan Chao, Lian Ni, Hao Zhimin, Sun Yujie, Wang Yan, Gu Heng, Chen Min. Expression of proprotein convertase subtilisin/kexin type 9 in the plasma of patients with psoriasis and its effect on the activation of peripheral CD4+ T cells [J]. Chinese Journal of Dermatology, 2019, 52(2): 90-93.
[15]	Guan Xin, Zhang Chunlei. Evaluation of efficacy of infliximab in the long-term treatment of moderate and severe psoriasis vulgaris [J]. Chinese Journal of Dermatology, 2019, 52(2): 86-89.

Significance of Protein Kinase Cζin Pathogenesis of Psoriasis

PDF

Like

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Metrics

Comments

Recommended 10