Abstract: Luo Yangyang, Tang Jinling, Sun Lei, Wei Zhu, Zeng Yinghong, Tang Jianping Department of Dermatology, Hunan Children′s Hospital, Changsha 410007, China Corresponding author: Tang Jianping, Email: jpingtang@126.com 【Abstract】 A 10-year and 9-month-old female patient presented with skin rashes all over the body, fever and superficial lymphadenectasis for 18 days after an intravenous drip of fosfomycin. Skin examination showed generalized swollen erythema all over the body, whose surfaces were covered with a large number of sticky furfuraceous grey-white scales. Laboratory examination revealed markedly increased levels of alanine aminotransferase and aspartate aminotransferase, as well as an increased number of eosinophils. Histopatho-logical examination of skin lesions showed infiltration of scattered lymphocytes in the superficial dermis, as well as around skin appendages. Immunohistochemical study demonstrated that the infiltrating lymphocytes mainly included T lymphocytes, and no atypical cells were observed. The patient was diagnosed with drug-induced hypersensitivity syndrome. After the treatment with intravenous glucocorticoids, immunoglobulin and oral cyclosporine, favorable therapeutic effects were achieved.