Abstract: 【Abstract】 Objective To analyze types of mucosal candidiasis and drug resistance of relevant pathogens in a dermatology outpatient clinic in Taiyuan. Methods Clinical data were collected from 172 patients with mucosal candidiasis, who had positive fungal culture results, in the dermatology outpatient clinic of Shanxi Bethune Hospital from 2019 to 2020. Pathogens were identified by a molecular biological approach, and in vitro drug sensitivity test was performed. Results Among the 172 patients with mucosal candidiasis, 142 （82.6%） had vulvovaginal candidiasis, 24 （14.0%） had candidal balanoposthitis, and 6 （3.5%） had oral candidiasis; 3 patients were aged ≤ 18 years, 155 were aged 19 - 59 years, and 14 were aged ≥ 60 years, and the proportion of patients with vulvovaginal candidiasis significantly differed among the above 3 age groups （2/3, 134/155［86.45%］, 6/14, respectively; χ2 = 14.29, P < 0.05）. Molecular biological identification showed that all the 172 isolated strains belonged to the genus Candida, including 165 strains of Candida albicans （95.9%）, 5 strains of Candida glabrata （2.9%）, and 2 strains of Candida parapsilosis （1.2%）; the sensitivity to common antifungal agents including flucytosine, amphotericin B, fluconazole, itraconazole and voriconazole was 95.9%, 100.0%, 62.2%, 47.1% and 56.4%, respectively. Conclusion In the dermatology outpatient clinic of Shanxi Bethune Hospital, vulvovaginal candidiasis was the most common type of mucosal candidiasis, and the main pathogen was Candida albicans; the Candida isolates showed high sensitivity to flucytosine and amphotericin B.

Key words: Candidiasis, vulvovaginal, Candidiasis, oral, Candida albicans, Candida glabrata, Microbial sensitivity tests