NLRP3炎性小体与皮肤病

doi:10.35541/cjd.20190023

Abstract

Abstract: 【Abstract】 NOD-like receptor protein 3 （NLRP3） inflammasomes play an important role in innate immunity. It can induce the maturation and release of cytokines interleukin （IL）-1β and IL-18 by activating caspase-1, and participate in a variety of host immunoinflammatory responses. Once the regulation of NLRP3 inflammasomes is unbalanced, excess IL-1β and IL-18 may be produced, triggering a series of inflammatory diseases. NLRP3 inflammasome activation plays important roles in skin diseases such as acne, psoriasis, pyoderma gangrenosum, polymyositis/dermatomyositis and bullous pemphigoid. This review summarizes research progress in NLRP3 inflammasomes in skin diseases.

Key words: Inflammasomes, Interleukin-1beta, Interleukin-18, Skin diseases, NLRP3

Lu Haojie, Song Xiuzu. NLRP3 inflammasomes and skin diseases[J]. Chinese Journal of Dermatology, 2020, 53(3): 236-238.doi:10.35541/cjd.20190023

References ［28］

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NLRP3 inflammasomes and skin diseases

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