中华皮肤科杂志 ›› 2006, Vol. 39 ›› Issue (1): 32-34.

• 论著 • 上一篇    下一篇

单频准分子光治疗白癜风的临床研究

郭静, 项蕾红, 郑志忠, 傅雯雯, 金以, 祝绿川   

  1. 复旦大学附属华山医院皮肤科 上海 200040
  • 收稿日期:2005-04-11 发布日期:2006-01-15

Treatment of vitiligo with the monochromatic excimer light 308-nm

GUO Jing, XIANG Lei-hong, ZHENG Zhi-zhong, FU Wen-wen, JIN Yi, ZHU Lu-chuan   

  1. Department of Dermatology, Hua Shan Hospital, Fu Dan University, Shanghai 200040, China
  • Received:2005-04-11 Published:2006-01-15

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摘要： 目的 研究观察单频准分子光308nm局部照射治疗白癜风的临床疗效,评估其安全性.方法 对77例不同临床类型的白癜风患者的201处皮损进行局部照射,每周1次,随访3-6个月.结果 经过准分子光局部照射平均18次,86.6%皮损有不同程度色素恢复,色素恢复随疗程延长而增加,照射24次总有效率为71.0%,显效率为51.6%.躯干、颈部和头面部疗效优于四肢及手足;泛发型和节段型白癜风疗效尤佳.主要不良反应为局部水疱和疼痛,患者能耐受.结论 准分子光局部照射治疗白癜风疗效显著,且不良反应少.

关键词: 白癜风, 单频准分子光, 疗效

Abstract: Objective To evaluate the efficacy and tolerance of monochromatic excimer light (MEL) 308 nm in the treatment of vitiligo.Methods Seventy-seven patients were enrolled in the prospective and open clinical study.Two-hundred and one lesions were subjected to local phototherapy of MEL 308-nm once a week for 3 to 6 months.Results Of these lesions,86.6% obtained repigmentation at different degrees.The repigmentation was more obvious in lesions on the head,face,neck and trunk than in those on the limbs or extremities.Moreover,patients with generalized and segmental vitiligo got a better improvement than patients with other types of vitiligo.Conclusion MEL 308-nm is effective in the treatment of vitiligo without obvious adverse effects.

Key words: Vitiligo, Monochromatic excimer light, Efficacy