中华皮肤科杂志 ›› 2020, Vol. 53 ›› Issue (12): 1026-1028.doi: 10.35541/cjd.20190641

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皮肤组织常驻记忆T细胞在白癜风炎症反应中的作用

陆豪杰    宋秀祖   

  1. 浙江中医药大学附属杭州第三人民医院皮肤科,杭州  310009
  • 收稿日期:2019-06-04 修回日期:2020-02-26 发布日期:2020-12-02
  • 通讯作者: 宋秀祖 E-mail:songxiuzu@sina.com.cn
  • 基金资助:
    国家自然科学基金(81872517);浙江省基础公益研究计划项目(LGF18H110001);杭州市科技计划项目(20130733Q24)

Role of skin-resident memory T cells in inflammatory response in vitiligo

Lu Haojie, Song Xiuzu   

  1. Department of Dermatology, The Third People′s Hospital of Hangzhou Affiliated to Zhejiang Chinese Medical University, Hangzhou 310009, China
  • Received:2019-06-04 Revised:2020-02-26 Published:2020-12-02
  • Contact: Song Xiuzu E-mail:songxiuzu@sina.com.cn
  • Supported by:
    National Natural Science Foundation of China (81872517); Zhejiang Basic Public Welfare Research Project(LGF18H110001); Hangzhou Science and Technology Planning Project(20130733Q24)

摘要: 【摘要】 组织常驻记忆T细胞由初始T细胞受到刺激后形成,并驻留在外周组织,介导机体对类似刺激迅速产生免疫反应。虽然这种免疫反应有助于保护机体对抗局部感染,但在自身免疫相关性皮肤病如白癜风中组织常驻记忆T细胞在皮肤的长时间驻留会导致疾病反复发作。本文对组织常驻记忆T细胞与白癜风之间的关系及潜在治疗靶点进行综述。

关键词: 白癜风, T淋巴细胞亚群, 复发, 组织常驻记忆T细胞

Abstract: 【Abstract】 Tissue-resident memory T(TRM)cells are derived from stimulated primary T cells and reside in peripheral tissues, mediating rapid immune responses of the host to similar stimuli. Although this immune response helps protect the host against local infections, long-term residence of TRM cells in the skin can lead to repeated attacks of autoimmune-related skin diseases such as vitiligo. This review summarizes the relationship between TRM cells and vitiligo as well as potential therapeutic targets.

Key words: Vitiligo, T-lymphocyte subsets, Recurrence, Tissue-resident memory T cells

引用本文

陆豪杰 宋秀祖. 皮肤组织常驻记忆T细胞在白癜风炎症反应中的作用[J]. 中华皮肤科杂志, 2020,53(12):1026-1028. doi:10.35541/cjd.20190641

Lu Haojie, Song Xiuzu. Role of skin-resident memory T cells in inflammatory response in vitiligo[J]. Chinese Journal of Dermatology, 2020, 53(12): 1026-1028.doi:10.35541/cjd.20190641