黑素细胞及相关细胞群参与白癜风发病的研究进展

doi:10.35541/cjd.20190353

中华皮肤科杂志 ›› 2020, Vol. 53 ›› Issue (9): 751-754.doi: 10.35541/cjd.20190353

黑素细胞及相关细胞群参与白癜风发病的研究进展

许爱娥周妙妮林福全

杭州市第三人民医院皮肤科 310009

收稿日期:2019-03-04 修回日期:2020-01-20 发布日期:2020-08-31
通讯作者: 许爱娥 E-mail:xuaiehz@msn.com
基金资助:
国家自然科学基金（81773335、81803131、81602755）；浙江省自然科学基金（LY18H110001、LGF18H110002）

Role of melanocytes and relevant cell populations in the occurrence of vitiligo

Xu Ai′e, Zhou Miaoni, Lin Fuquan

Department of Dermatology, The Third People′s Hospital of Hangzhou, Hangzhou 310009, China

Received:2019-03-04 Revised:2020-01-20 Published:2020-08-31
Contact: Xu Ai′e E-mail:xuaiehz@msn.com
Supported by:
National Natural Science Foundation of China （81773335, 81803131, 81602755）; Natural Science Foundation of Zhejiang Province of China （LY18H110001, LGF18H110002）

摘要/Abstract

摘要： 【摘要】白癜风发病机制复杂，黑素细胞缺失是核心。目前认为除黑素细胞自身缺陷外，表皮和真皮细胞群的功能异常及其与黑素细胞的交互作用对白癜风的发病同样重要，充分而准确地了解不同病期白癜风皮肤全层细胞、组织的病理生理状态，对认识和治疗白癜风有重要作用。本文旨在综述黑素细胞及相关细胞群在白癜风发病中作用的研究进展。

关键词: 白癜风, 黑素细胞, 角蛋白细胞, 成纤维细胞, CD4阳性T淋巴细胞, CD8阳性T淋巴细胞, 记忆T细胞

Abstract: 【Abstract】 The pathogenesis of vitiligo is complicated, and the loss of melanocytes plays a central role. Besides deficiency in melanocytes, it is considered that dysfunction of epidermal and dermal cell populations as well as their interaction with melanocytes also play important roles in the occurrence of vitiligo, Thus, it is necessary for understanding and treatment of vitiligoto to fully and accurately understand pathophysiological states of full-thickness vitiliginous skin cells and tissues at different stages. This review aims to summarize the research progress in the role of melanocytes and related cell populations in the occurrence of vitiligo.

Key words: Vitiligo, Melanocytes, Keratinocytes, Fibroblasts, CD4-positive T-lymphocytes, CD8-positive T-lymphocytes, Memory T cells

许爱娥周妙妮林福全. 黑素细胞及相关细胞群参与白癜风发病的研究进展[J]. 中华皮肤科杂志, 2020,53(9):751-754. doi:10.35541/cjd.20190353

Xu Ai′e, Zhou Miaoni, Lin Fuquan. Role of melanocytes and relevant cell populations in the occurrence of vitiligo[J]. Chinese Journal of Dermatology, 2020, 53(9): 751-754.doi:10.35541/cjd.20190353

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黑素细胞及相关细胞群参与白癜风发病的研究进展

Role of melanocytes and relevant cell populations in the occurrence of vitiligo

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