中华皮肤科杂志 ›› 2005, Vol. 38 ›› Issue (1): 32-34.

• 论著 • 上一篇    下一篇

寻常型白癜风临床特征及遗传传递方式分析

刘江波1, 桂金萍2, 熊全庚2, 王红艳1, 李明1, 高敏1, 杨杰1, 杨青1, 贾卫华3, 杨森1, 张学军1   

  1. 1. 安徽医科大学皮肤病研究所暨第一附属医院皮肤科, 合肥230032;
    2. 湖北襄樊铁路医院白癜风研究所;
    3. 中山大学附属肿瘤医院
  • 收稿日期:2004-02-12 出版日期:2005-01-15 发布日期:2005-01-15
  • 通讯作者: 张学军,E-mail:ayzxj@mail.hf.ah.cn E-mail:ayzxj@mail.hf.ah.cn
  • 基金资助:
    国家863基金资助项目(2001AA227031)

Clinical Features and the Mode of Genetic Transmission in Vitiligo Vulgaris

LIU Jiang-bo1, GUI Jin-ping2, XIONG Quan-geng2, WANG Hong-yan1, LI Ming1, GAO Min1, YANG Jie1, YANG Qing1, JIA Wei-hua3, YANG Sen1, ZHANG Xue-jun1   

  1. Institute of Dermatology & Department of Dermatology of the First Affiliated Hospital, Anhui Medical University, Hefei, Anhui 230022, China
  • Received:2004-02-12 Online:2005-01-15 Published:2005-01-15

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摘要： 目的 分析中国汉族寻常型白癜风的临床特征及家族遗传特征,探索其可能的遗传传递方式。方法 以调查表的形式收集患者的临床资料及家系资料,用Epi Info 5.0及SPSS 10.0软件包进行统计学分析,用SAGE3.1进行遗传传递方式的复合分离分析。结果 寻常型白癜风的发病年龄为(19.02±12.58)岁,无性别差异(P=0.54);男女先证者疾病轻重程度(P=0.66)、发病季节分布(P=0.302)差异亦无统计学意义;女性患者的伴发疾病率显著高于男性(P=0.03),尤以甲亢为著(P=0.02)。患者亲属中白癜风患病率较一般人群显著增高。寻常型白癜风符合多基因累加遗传传递方式(P>0.05)。结论 寻常型白癜风的发生无性别差异,但存在明显的家族聚集性,该病的发生可能是由多基因累加遗传效应及环境因素共同作用的结果。

关键词: 白癜风, 遗传流行病学

Abstract: Objective To analyze the clinical features and to explore the potential mode of genetic transmission of vitiligo vulgaris in Chinese Han population. Methods Information on the clinical features and the familial history of patients with vitiligo vulgaris was collected by a uniform questionnaire. The data were inputted into a data base, then analyzed by Epi Info 5.0 and SPSS 10.0 software packages. A complex segregation analysis was conducted using the REGTL program in SAGE 3.1 package in order to propose the putative mode of genetic transmission for vitiligo vulgaris. Results The mean age of onset of vitiligo vulgaris of the males and females was about 19 years old. In the severity of the disease and the season of onset, there was no significant difference between males and females. For the patients with vitiligo vulgaris, there was a female preponderance of complicating with autoimmune disorders, especially hyperthyroidism. The prevalence rates of vitiligo in patients' relatives were significantly higher than that in general population. The mode of transmission of vitiligo vulgaris was one of the multifactorial inheritance according to the results obtained by the complex segregation analysis. Conclusions There are no differences in the prevalence and the age of onset between males and females patients. There is a marked familial aggregation in the patients with vitiligo vulgaris. The familial clustering might result from the polygenic additive genetic background and common environmental factors. It is suggested that vitiligo vulgaris be a multifactorial complex disease.

Key words: Vitiligo, Genetic epidemiology