中华皮肤科杂志 ›› 2005, Vol. 38 ›› Issue (3): 154-156.

• 论著 • 上一篇    下一篇

p27kip1和ki-67在寻常性银屑病皮损中的表达

郜玉玲1, 王桂芝3, 林桂铭2   

  1. 1. 青岛市市立医院皮肤科 266011;
    2. 青岛市市立医院皮肤病理室 266011;
    3. 青岛大学医学院附属医院皮肤科
  • 收稿日期:2004-03-18 出版日期:2005-03-15 发布日期:2005-03-15
  • 通讯作者: 王桂芝, E-mail:wangguizhi1956@163.com E-mail:wangguizhi1956@163.com

Effects of p27kip1 and KI-67 in Patients with Psoriasis Vulgaris

GAO Yu-ling1, WANG Gui-zhi3, LIN Gui-ming2   

  1. Municipal Hospital, Qingdao 266001, China
  • Received:2004-03-18 Online:2005-03-15 Published:2005-03-15

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摘要： 目的 检测p27kip1和ki-67在寻常性银屑病皮损中的表达水平,探讨其在银屑病发病中的意义。方法 用免疫组化SP法检测细胞周期素依赖性蛋白激酶抑制剂p27kip1和增殖细胞核抗原ki-67在寻常性银屑病皮损及正常人皮肤中的表达水平。结果 慢性斑块状与滴状皮损中p27kip1表达水平均显著低于正常人对照组(P<0.05和0.001),而慢性斑块状与滴状差异无统计学意义(P>0.05)。慢性斑块状与滴状皮损中ki-67表达水平均显著高于正常人对照组(P均<0.01);慢性斑块状皮损中ki-67表达水平低于滴状(P<0.01)。在寻常性银屑病皮损中,p27kip1表达和ki-67表达未发现相关性(r=0.08,P>0.05)。结论 银屑病的发生可能与p27kip1下调有关;而ki-67的表达水平反映了角质形成细胞增殖状态。

关键词: 银屑病, p27kip1, Ki-67抗原

Abstract: Objective To investigate the levels of p27kip1 and ki-67 of psoriatic lesions in patients with psoriasis vulgaris.Methods The expression of p27kip1 and ki-67 in psoriatic lesions was determined by immunohistochemistry.Results The level of p27kip1 expression was significantly lower in the plaque-form lesions of the patients with psoriasis than that in the normal controls(P<0.05).The expression level of p27kip1 significantly decreased in the guttate lesions of the patients with psoriasis compared with the normal controls (P<0.001).Between the guttate and plaque-form lesions,there was no significant difference in the expression level of p27kip1 (P>0.05).The expression level of ki-67 was significantly higher in plaque-form lesions than that in the normal controls(P<0.01).The expression level of ki-67 significantly increased in guttate lesions compared with the normal controls(P<0.001).The expression level of ki-67 was significantly higher in guttate lesions than that of the plaque-form lesions (P<0.001).There was no correlation between the expression level of p27kip1 and ki-67 in psoriatic lesions (r=0.08).Conclusions The down-regulation of p27kip1 may be involved in the pathogenesis of psoriasis vulgaris.And the expression level of ki-67 may reflect the overproliferation of keratinocytes in psoriasis vulgaris.

Key words: Psoriasis, p27kip1, Ki-67 antigen