中华皮肤科杂志 ›› 1999, Vol. 32 ›› Issue (6): 376-378.

• 论著 • 上一篇    下一篇

不同肤色人种皮肤对硫酸月桂酯钠引发刺激性接触性皮炎反应差异的比较

陆洪光1, 张宁1, Graves C2, Marks R2   

  1. 1. 贵阳医学院附属医院皮肤科 550001;
    2. 英国威尔士大学医学院皮肤科
  • 收稿日期:1998-11-17 修回日期:1999-04-28 出版日期:1999-12-15 发布日期:1999-12-15

Racial Difference in Sodium Lauryl Sulphate Induced Cutaneous Irritation-A Comparison Between the Skin of White, Black and Oriental Race

LU Hongguang1, ZHANC Ning1, CRAVES C2   

  1. Department of Dermatology Affilialed Hospital of Cuiyang Medical College, Culyang 550001
  • Received:1998-11-17 Revised:1999-04-28 Online:1999-12-15 Published:1999-12-15

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摘要： 目的 评估不同肤色人种皮肤对化学刺激物的敏感性.方法 用多个浓度的硫酸月桂酯钠对32例健康志愿者(黑种人8例,白种人16例,黄种人8例)背部皮肤进行斑贴试验.结果 显示黑种人组最小红斑刺激量高于白种人组(P<0.05)和黄种人组(P>0.05).然而在相同浓度的硫酸月桂酯钠刺激部位,黑种人、白种人和黄种人3组经表皮水分散失和真皮浅层微血管血流量值无显著性差异.黑种人、白种人和黄种人3组经表皮水分散失和真皮浅层微血管血流量值分别与硫酸月佳酯钠刺激浓度有明显的剂量应答关系,并且3组经表皮水分散失值与临床观察指数值之间呈显著正相关(黑种人组:r=0.83,P<0.01;白种人组:r=0.92,P<0.01;黄种人组:r=0.89,P结论 与白种人和苗种人相比,黑种人皮肤对硫酸月桂酯钠刺激同样较敏感.

关键词: 皮炎,刺激性, 硫酸月桂酯钠, 皮肤

Abstract: Objective To determine the susceptibility to an itritant in the skin of different races.Methods A total of 32 subjects were included in the study and divided into three race groups: 8 Blacks, 16Caucasians and 8 Orientals.All volunteers were given patch test with sodium lauryl sulphate(SLS) (0.25%~2%) to the skin of upper back for 24 hours.The skin response was evaluated after removing test chambers.Results It was shown that minimal irritant dose(MID) levels were significantly higher in Blacks than those in Caucasions (P<0.05) but not in Orientals (P>0.05).It was observed that values of the transepidermal water loss (TEWL) and laser doppler velocimetry(LDV) increased significantly along with the increase of dosage of SLS in each of three race groups.There was no difference in values of TEWL and LDV among Caucasion,Black and Oriental groups.Furthermore, it was found that TEWL values significantly correlated with the visual scores in the three groups(Blacks r=0.83,P<0.01, Caucasions r=0.92, P<0.01, Orientals r=0.89,P<0.01).Conclusion The resuts indicate that dark skin has the same sensitive response to SLS itritation as light skin.

Key words: Dermatitis,irritant, Sodium lauryl sulphate, Skin