中华皮肤科杂志 ›› 2019, Vol. 52 ›› Issue (6): 414-419.doi: 10.3760/cma.j.issn.0412-4030.2019.06.008

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高频超声检测健康成人皮肤厚度及回声密度

于瑞星1    薛珂2    沈雪3    崔勇1   

  1. 1中日友好医院皮肤病与性病科，北京  100029；2北京协和医学院研究生院  中日友好医院皮肤病与性病科，北京  100029；3安徽医科大学第一附属医院皮肤性病科  皮肤病研究所，合肥  230000
  • 收稿日期:2018-12-11 修回日期:2019-05-07 发布日期:2019-06-03
  • 通讯作者: 崔勇 E-mail:wuhucuiyong@vip.163.com
  • 基金资助:
    中国人群皮肤影像资源库项目开放式研究基金（CSID-ORF-201711）；米尔斯坦亚美医学基金会项目（MMAAP2016023）；中日友好医院院级科研基金资助项目（2017-2-QN-20）；《中国数字医学》杂志社课题（2018-HX-68）

Detection of skin thickness and echo density in healthy adults by using high?frequency ultrasound

Yu Ruixing1, Xue Ke2, Shen Xue3, Cui Yong1#br#   

  1. 1Department of Dermatology and Venereology, China⁃Japan Friendship Hospital, Beijing 100029, China; 2Graduate School of Peking Union Medical College, Chinese Academy of Medical Sciences and Peking Union Medical College, Department of Dermatology and Venereology, China⁃Japan Friendship Hospital, Beijing 100029, China; 3Institute of Dermatology and Department of Dermatology, First Affiliated Hospital, Anhui Medical University, Hefei 230000, China
  • Received:2018-12-11 Revised:2019-05-07 Published:2019-06-03
  • Contact: Cui Yong E-mail:wuhucuiyong@vip.163.com
  • Supported by:
    Open Research Funding of China Skin Image Database （CSID-ORF-201711）; Milstein Medical Asian American Partnership Foundation （MMAAP2016023）; Scientific Research Fund of China-Japan Friendship Hospital （2017-2-QN-20）; China Digital Medicine Magazine Fund （2018-HX-68）

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摘要： 【摘要】 目的 利用高频超声测量健康人多个部位皮肤厚度及回声密度。方法 在中日友好医院皮肤病与性病科于2018年6 - 12月招募50名健康志愿者，女33例，男17例，年龄22 ~ 69岁。采用22 MHz高频超声检测前额、面颊、前胸、腹部、上臂内外侧、前臂内外侧、大腿内外侧、小腿内外侧12个部位的表皮、真皮、表真皮厚度及皮肤回声密度。两独立样本均数比较采用t检验，多组间均数比较采用单因素方差分析。结果 不同解剖部位皮肤高频超声图像不同。12个部位之间表皮、真皮、表真皮厚度及回声密度差异均有统计学意义（P < 0.05），其中表皮最厚的部位为大腿内侧（160.68 μm ± 25.71 μm），真皮最厚的部位为面颊（1 828.78 μm ± 399.10 μm），表真皮最厚的部位为面颊（1 943.48 μm ± 402.4 μm）。表皮回声密度最大的部位为小腿内侧（152.27 ± 21.56），真皮最大的部位为前臂内侧（52.71 ± 15.57），表真皮最大的部位为前臂内侧（62.56 ± 15.76）。男性前额、面颊、前臂内侧的表皮、真皮、表真皮厚度均大于女性（≤ 0.05或 < 0.01），男性前额、面颊、小腿外侧真皮、表真皮回声密度低于女性（P < 0.05或0.01）。结论 健康成人不同解剖部位及不同性别的皮肤厚度与回声密度有差异。

关键词: 超声检查, 表皮, 真皮, 皮肤厚度, 皮肤回声密度

Abstract: 【Abstract】    Objective    To measure the thickness and echo density of the skin at multiple sites of healthy adults by using high-frequency ultrasound. Methods    A total of 50 healthy volunteers were enrolled from Department of Dermatology and Venereology, China-Japan Friendship Hospital between June and December in 2018, including 33 females and 17 males aged 22 - 69 years. The thickness and echo density of the epidermis, dermis and epidermis-dermis layer were detected by using high-frequency ultrasound at 12 sites, including the forehead, cheek, chest, abdomen, and the inner and outer sides of the upper arm, forearm, thigh and leg. The means of two groups were compared by using t test, and means of several groups were compared by using one-way analysis of variation. Results    High-frequency skin ultrasound images differed among different anatomical sites. There were significant differences in the thickness and echo density of the epidermis, dermis and epidermis-dermis layer among the 12 sites （P < 0.05）. The epidermis was thickest at the inner side of the thigh （160.68 μm ± 25.71 μm）, the dermis was thickest at the cheek（1 828.78 μm ± 399.10 μm）, and the epidermis-dermis layer was thickest at the cheek（1 943.48 μm ± 402.4 μm）. The echo density of the epidermis, dermis and epidermis-dermis layer was highest at the inner side of the leg （152.27 ± 21.56）, forearm （52.71 ± 15.57） and forearm （62.56 ± 15.76） respectively. The thickness of the epidermis, dermis and epidermis-dermis layer at the forehead, cheek and the inner side of the forearm was significantly higher in male volunteers than in female volunteers （P ≤ 0.05 or < 0.01）, while the echo density of the dermis and epidermis-dermis layer at the forehead, cheek and the outer side of the leg was significantly lower in male volunteers than in female volunteers （P < 0.05 or 0.01）. Conclusion    Differences exist in skin thickness and echo density among different anato mical sites and between male and female healthy adults.

Key words: Ultrasonography, Epidermis, Dermis, Skin thickness, Skin echo density

引用本文

于瑞星 薛珂 沈雪 崔勇. 高频超声检测健康成人皮肤厚度及回声密度[J]. 中华皮肤科杂志, 2019,52(6):414-419. doi:10.3760/cma.j.issn.0412-4030.2019.06.008

Yu Ruixing, Xue Ke, Shen Xue, Cui Yong. Detection of skin thickness and echo density in healthy adults by using high?frequency ultrasound[J]. Chinese Journal of Dermatology, 2019, 52(6): 414-419.doi:10.3760/cma.j.issn.0412-4030.2019.06.008