中华皮肤科杂志 ›› 2023, Vol. 56 ›› Issue (1): 35-39.doi: 10.35541/cjd.20220672

• 论著 • 上一篇    下一篇

【开放获取】健康儿童皮肤透皮失水率与角质层含水量的相关性研究

赖庆松1    陈爱祺1    赖宇霖1    叶理2    王晓华2    蔄茂强2   

  1. 1广东省普宁市公共卫生医学中心，普宁  515300；2南方医科大学皮肤病医院皮肤生理研究及护肤品研发功效评价中心，广州  510091
  • 收稿日期:2022-09-21 修回日期:2022-12-05 发布日期:2023-01-03
  • 通讯作者: 蔄茂强 E-mail:mqman@hotmail.com

Correlations between transepidermal water loss rates and stratum corneum hydration levels in healthy children

Lai Qingsong1, Chen Aiqi1, Lai Yulin1, Ye Li2, Wang Xiaohua2, Man Maoqiang2   

  1. 1Medical Center for Public Health of Puning, Puning 515300, Guangdong, China; 2Center for Research on Skin Physiology and Development of Skin Care Products, Dermatology Hospital of Southern Medical University, Guangzhou 510091, China
  • Received:2022-09-21 Revised:2022-12-05 Published:2023-01-03
  • Contact: Man Maoqiang E-mail:mqman@hotmail.com

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摘要： 【摘要】 目的 探讨角质层含水量与透皮失水率的相关性。方法 2021年10月至2022年6月在普宁市公共健康医疗中心、2所幼儿园及2所小学招募 ≤ 17岁健康儿童。用皮肤生理功能测量仪测量健康儿童左前臂屈侧和右胫前部位的透皮失水率和角质层含水量，采用Pearson相关分析法分析不同年龄、性别儿童的透皮失水率与角质层含水量的相关性。结果 共招募1 396例健康儿童，年龄1个月至17岁，男783例、女613例。在1 ~ < 12个月组，除男童前臂部位的皮肤透皮失水率与角质层含水量无显著相关性外，男童胫前和女童前臂及胫前部位的透皮失水率与角质层含水量均呈正相关（r值为0.283、0.404、0.420，均P < 0.05）；在1 ~ 2岁组，男童前臂和女童胫前部位的皮肤透皮失水率与角质层含水量无显著相关性，而男童胫前和女童前臂部位的透皮失水率与角质层含水量均呈正相关（r值为0.370、0.419，均P < 0.01）；在3 ~ 5岁组和6 ~ 11岁组，除6 ~ 11岁组男童胫前的透皮失水率与角质层含水量无显著相关性外，两组男女性其他部位的透皮失水率与角质层含水量均呈显著正相关（r值为0.172 ~ 0.293，均P < 0.05）；12 ~ 17岁组，男女性前臂及胫前部位的透皮失水率与角质层含水量均呈显著正相关（r值为0.269 ~ 0.485，均P < 0.001）。结论 健康儿童前臂屈侧和胫前部位的透皮失水率与角质层含水量呈正相关，且随年龄增大，此正相关性有增加趋势。

关键词: 表皮, 儿童, 青少年, 角质层含水量, 表皮通透屏障功能, 透皮失水率

Abstract: 【Abstract】 Objective To determine whether the transepidermal water loss rate （TEWL） is correlated with the stratum corneum （SC） hydration level. Methods Healthy children aged ≤ 17 years were enrolled from Medical Center for Public Health of Puning, 2 kindergartens and 2 primary schools, from October 2021 to June 2022. TEWL and SC hydration levels were measured on the left forearm and right anterior shank using a device for measuring skin physiological funcitons. Pearson correlation analysis was used to determine the correlations between TEWL and SC hydration levels in children of different ages and genders. Results A total of 1 396 healthy children were enrolled, aged from 1 month to 17 years. Among them, 783 were male children and 613 were female children. In children aged 1 to < 12 months, no correlation was observed between TEWL and SC hydration levels on the forearms of male children, while TEWL was positively correlated with SC hydration levels on the anterior shanks of male children, as well as on the forearm and anterior shanks of female children （r = 0.283, 0.404, 0.420, respectively, all P < 0.05）. In children aged 1 to 2 years, positive correlations were observed between the above two indicators on the anterior shanks of male children and forearms of female children （r = 0.370, 0.419, respectively, both P < 0.01）, while there were no correlations between the two indicators on the anterior shanks of female children or forearms of male children. Positive correlations were observed between TEWL and SC hydration levels on both the forearms and anterior shanks of female children and the forearms of male children aged 3 to 5 years and 6 to 11 years （r values ranging from 0.172 to 0.293, all P < 0.05）, but not on the anterior shanks of male children aged from 6 to 11 years. The group aged 12 to 17 years exhibited significantly positive correlations between TEWL and SC hydration levels on both the anterior shanks and forearms of male and female children （r values ranging from 0.269 to 0.485, all P < 0.001）. Conclusion SC hydration levels are positively correlated with TEWL on the anterior shanks and forearms of healthy children, and the degree of correlation tends to increase with age.

Key words: Epidermis, Child, Adolescent, Stratum corneum hydration, Epidermal permeability barrier, Transepidermal water loss