中华皮肤科杂志 ›› 2005, Vol. 38 ›› Issue (9): 560-562.

• 论著 • 上一篇    下一篇

特应性皮炎和湿疹皮肤金黄色葡萄球菌肠毒素及中毒休克综合征毒素-1的检测

陈文琦1, 张美华1, 毕志刚1, 梅亚宁2, 赵辨1   

  1. 1. 南京医科大学第一附属医院皮肤科, 210029;
    2. 南京医科大学第一附属医院临床检验中心细菌室, 210029
  • 收稿日期:2004-09-06 发布日期:2005-09-15

Study on the Superantigen Production by Skin-Colonizing Staphylococcus aureus in Patients with Atopic Dermatitis and Eczema

CHEN Wen-qi1, ZHANG Mei-hua1, BI Zhi-gang1, MEI Ya-ning2, ZHAO Bian1   

  1. Department of Dermatology, The First Affiliated Hospital of Nanjing Medical Univesity, Nanjing 210029, China
  • Received:2004-09-06 Published:2005-09-15

PDF

65

赞

摘要： 目的 探讨皮肤金黄色葡萄球菌(金葡菌)肠毒素及中毒休克综合征毒素-1(TSST-1)在特应性皮炎及湿疹中的致病作用。方法 反向被动乳胶凝集法测定来自117例特应性皮炎和199例湿疹患者皮肤共140株金葡菌的肠毒素/TSST-1。结果 140株金葡菌中60株产生超抗原,阳性率为42.9%,其中43株只产生一种超抗原,17株产生至少两种超抗原。特应性皮炎组超抗原总阳性率为51.5%,皮损与非皮损处无差别。湿疹组超抗原总阳性率为34.7%,阳性株均为皮损处菌。特应性皮炎组超抗原总阳性率、皮损处超抗原总阳性率及中毒休克综合征毒素-1阳性率均高于湿疹组。结论 与湿疹相比,特应性皮炎与金葡菌超抗原的关系较为密切。

关键词: 皮炎, 特应性, 湿疹, 葡萄球菌, 金黄色, 超抗原

Abstract: Objective To determine the potential impact of superantigens produced by skin-colonizing Staphylococcus aureus in patients with atopic dermatitis and eczema. Methods Of 117 patients with atopic dermatitis and 199 with eczema, 140 Staphylococcus aureus strains were isolated from the skin specimens. Superantigens were detected with reverse passive latex agglutination. Results Among 140 Staphylococcus aureus strains, 60 (42.9%) produced superantigens, among which 43 produced one kind of superantigens only and 17 produced at least two kinds. Of strains isolated from atopic dermatitis, 51.5% produced superantigens and no significant difference was seen in superantigen production between lesional and non-lesional strains in atopic dermatitis. Of strains isolated from eczema patients, 34.7% (all were lesional strains) produced superantigens. The positive rates of total superantigens, lesional superantigens and toxic shock syndrome toxin-1 production were all higher in the strains from atopic dermatitis than in those from eczema. Conclusions Superantigen production by skin-colonizing Staphylococcus aureus probably plays a more important role in atopic dermatitis than that in eczema. However, further studies are necessary to validate its importance.

Key words: Dermatitis, atopic, Eczema, Staphylococcus aureus, Superantigens