宏基因组学在特应性皮炎研究中的应用进展

doi:10.35541/cjd.20190449

中华皮肤科杂志 ›› 2020, Vol. 53 ›› Issue (4): 311-314.doi: 10.35541/cjd.20190449

• 综述 • 上一篇

宏基因组学在特应性皮炎研究中的应用进展

何素玲田歆陈丽洁李俊龙王建琴刘玉梅

广州医科大学皮肤病研究所广州市皮肤病防治所皮肤科 510095

收稿日期:2019-03-29 修回日期:2019-09-30 发布日期:2020-04-01
通讯作者: 王建琴；刘玉梅 E-mail:jianqinwang@foxmail.com; 1109180611@ qq.com
基金资助:
广州市科技计划（201904010082）；广州市卫生健康科技项目（20191A011070）

Application of metagenomics in atopic dermatitis

He Suling, Tian Xin, Chen Lijie, Li Junlong, Wang Jianqin, Liu Yumei

Department of Dermatology, Guangzhou Institute of Dermatology, Institute of Dermatology, Guangzhou Medical University, Guangzhou 510095, China

Received:2019-03-29 Revised:2019-09-30 Published:2020-04-01
Contact: Wang Jianqin; Liu Yumei E-mail:jianqinwang@foxmail.com; 1109180611@ qq.com
Supported by:
Science and Technology Planning Project of Guangzhou （201904010082）; Health Science and Technology Project of Guangzhou （20191A011070）

摘要/Abstract

摘要： 【摘要】人和动物的宏基因组分析表明，特应性皮炎（AD）与肠道和皮肤微生物群的失调有关。微生物多样性的减少可以导致皮肤屏障受损及AD病情加重，肠道微生物群可能通过免疫、代谢和神经内分泌途径参与AD的发生发展。本文综述了宏基因组学在AD微生物研究及治疗领域中的最新应用进展，总结了微生物群落介导AD发病过程中的可能机制，为针对AD的微生态治疗应用提供理论参考。

关键词: 皮炎')">皮炎, 特应性；宏基因组学；微生物群落；微生态治疗

Abstract: 【Abstract】 Metagenomic analyses of humans and animals have showed that atopic dermatitis （AD） is associated with microbiome dysbiosis in the gut and skin. Decrease of microbial diversity can cause damage to skin barrier and aggravation of AD, and gut microbiome may be involved in the occurrence and development of AD through immune, metabolic and neuroendocrine pathways. This review summarizes the latest advances in the application of metagenomics in the field of microbiological research in and treatment of AD, possible mechanisms underlying microbiome-mediated pathogenesis of AD, and provides a theoretical reference for the microecological therapy of AD.

Key words: Dermatitis, atopic, Metagenomics, Microbial consortia, Microecological therapy

何素玲田歆陈丽洁李俊龙王建琴刘玉梅. 宏基因组学在特应性皮炎研究中的应用进展[J]. 中华皮肤科杂志, 2020,53(4):311-314. doi:10.35541/cjd.20190449

He Suling, Tian Xin, Chen Lijie, Li Junlong, Wang Jianqin, Liu Yumei . Application of metagenomics in atopic dermatitis[J]. Chinese Journal of Dermatology, 2020, 53(4): 311-314.doi:10.35541/cjd.20190449

参考文献 34

［1］	Weidinger S, Beck LA, Bieber T, et al. Atopic dermatitis［J］. Nat Rev Dis Primers, 2018,4（1）:1. doi: 10.1038/s41572⁃018⁃0001⁃z.
［2］	Paller AS, Kong HH, Seed P, et al. The microbiome in patients with atopic dermatitis［J］. J Allergy Clin Immunol, 2019,143（1）:26⁃35. doi: 10.1016/j.jaci.2018.11.015.
［3］	Handelsman J, Rondon MR, Brady SF, et al. Molecular biological access to the chemistry of unknown soil microbes: a new frontier for natural products［J］. Chem Biol, 1998,5（10）:R245⁃249.
［4］	Chen K, Pachter L. Bioinformatics for whole⁃genome shotgun sequencing of microbial communities［J］. PLoS Comput Biol, 2005,1（2）:106⁃112. doi: 10.1371/journal.pcbi.0010024.
［5］	Sanger F, Nicklen S, Coulson AR. DNA sequencing with chain⁃terminating inhibitors［J］. Proc Natl Acad Sci U S A, 1977,74（12）:5463⁃5467. doi: 10.1073/pnas.74.12.5463.
［6］	Schadt EE, Turner S, Kasarskis A. A window into third⁃generation sequencing［J］. Hum Mol Genet, 2010,19（R2）:R227⁃240. doi: 10.1093/hmg/ddq416.
［7］	NIH HMP Working Group, Peterson J, Garges S, et al. The NIH human microbiome project［J］. Genome Res, 2009,19（12）:2317⁃2323. doi: 10.1101/gr.096651.109.
［8］	Martin TC, Visconti A, Spector TD, et al. Conducting metagenomic studies in microbiology and clinical research［J］. Appl Microbiol Biotechnol, 2018,102（20）:8629⁃8646. doi: 10.1007/s00253⁃018⁃9209⁃9.
［9］	Pascal M, Perez⁃Gordo M, Caballero T, et al. Microbiome and allergic diseases［J］. Front Immunol, 2018,9:1584. doi: 10.3389/fimmu.2018.01584.
［10］	Kim BE, Leung D. Significance of skin barrier dysfunction in atopic dermatitis［J］. Allergy Asthma Immunol Res, 2018,10（3）:207⁃215. doi: 10.4168/aair.2018.10.3.207.
［11］	Bending D, Ono M. Interplay between the skin barrier and immune cells in patients with atopic dermatitis unraveled by means of mathematical modeling［J］. J Allergy Clin Immunol, 2017,139（6）:1790⁃1792. doi: 10.1016/j.jaci.2017.03.015.
［12］	Clausen ML, Edslev SM, Andersen PS, et al. Staphylococcus aureus colonization in atopic eczema and its association with filaggrin gene mutations［J］. Br J Dermatol, 2017,177（5）:1394⁃1400. doi: 10.1111/bjd.15470.
［13］	Williams MR, Nakatsuji T, Sanford JA, et al. Staphylococcus aureus induces increased serine protease activity in keratinocytes［J］. J Invest Dermatol, 2017,137（2）:377⁃384. doi: 10.1016/j.jid. 2016.10.008.
［14］	Czarnowicki T, Krueger JG, Guttman⁃Yassky E. Novel concepts of prevention and treatment of atopic dermatitis through barrier and immune manipulations with implications for the atopic march［J］. J Allergy Clin Immunol, 2017,139（6）:1723⁃1734. doi: 10.1016/j.jaci.2017.04.004.
［15］	Chen YE, Tsao H. The skin microbiome: current perspectives and future challenges［J］. J Am Acad Dermatol, 2013,69（1）:143⁃155. doi: 10.1016/j.jaad.2013.01.016.
［16］	Oh J, Byrd AL, Deming C, et al. Biogeography and individuality shape function in the human skin metagenome［J］. Nature, 2014,514（7520）:59⁃64. doi: 10.1038/nature13786.
［17］	Nakatsuji T, Chen TH, Narala S, et al. Antimicrobials from human skin commensal bacteria protect against Staphylococcus aureus and are deficient in atopic dermatitis［J］. Sci Transl Med, 2017,9（378）. pii: eaah4680. doi: 10.1126/scitranslmed.aah4680.
［18］	Geoghegan JA, Irvine AD, Foster TJ. Staphylococcus aureus and atopic dermatitis: a complex and evolving relationship［J］. Trends Microbiol, 2018,26（6）:484⁃497. doi: 10.1016/j.tim.2017. 11.008.
［19］	Totté JE, van der Feltz WT, Hennekam M, et al. Prevalence and odds of Staphylococcus aureus carriage in atopic dermatitis: a systematic review and meta⁃analysis［J］. Br J Dermatol, 2016,175（4）:687⁃695. doi: 10.1111/bjd.14566.
［20］	Kong HH, Oh J, Deming C, et al. Temporal shifts in the skin microbiome associated with disease flares and treatment in children with atopic dermatitis［J］. Genome Res, 2012,22（5）:850⁃859. doi: 10.1101/gr.131029.111.
［21］	Lee SY, Lee E, Park YM, et al. Microbiome in the gut⁃skin axis in atopic dermatitis［J］. Allergy Asthma Immunol Res, 2018,10（4）:354⁃362. doi: 10.4168/aair.2018.10.4.354.
［22］	Abrahamsson TR, Jakobsson HE, Andersson AF, et al. Low diversity of the gut microbiota in infants with atopic eczema［J］. J Allergy Clin Immunol, 2012,129（2）:434⁃440, 440.e1⁃2. doi: 10.1016/j.jaci.2011.10.025.
［23］	Kim JE, Kim HS. Microbiome of the skin and gut in atopic dermatitis （ad）: understanding the pathophysiology and finding novel management strategies［J］. J Clin Med, 2019,8（4）. pii: E444. doi: 10.3390/jcm8040444.
［24］	Nowrouzian FL, Lina G, Hodille E, et al. Superantigens and adhesins of infant gut commensal Staphylococcus aureus strains and association with subsequent development of atopic eczema［J］. Br J Dermatol, 2017,176（2）:439⁃445. doi: 10.1111/bjd. 15138.
［25］	Dou J, Zeng J, Wu K, et al. Microbiosis in pathogenesis and intervention of atopic dermatitis［J］. Int Immunopharmacol, 2019,69:263⁃269. doi: 10.1016/j.intimp.2019.01.030.
［26］	Nakatsuji T, Chiang HI, Jiang SB, et al. The microbiome extends to subepidermal compartments of normal skin［J］. Nat Commun, 2013,4:1431. doi: 10.1038/ncomms2441.
［27］	Nakatsuji T, Chen TH, Two AM, et al. Staphylococcus aureus exploits epidermal barrier defects in atopic dermatitis to trigger cytokine expression［J］. J Invest Dermatol, 2016,136（11）:2192⁃2200. doi: 10.1016/j.jid.2016.05.127.
［28］	Mohajeri MH, Brummer R, Rastall RA, et al. The role of the microbiome for human health: from basic science to clinical applications［J］. Eur J Nutr, 2018,57（Suppl 1）:1⁃14. doi: 10. 1007/s00394⁃018⁃1703⁃4.
［29］	Kim HW, Hong R, Choi EY, et al. A probiotic mixture regulates T cell balance and reduces atopic dermatitis symptoms in mice［J］. Front Microbiol, 2018,9:2414. doi: 10.3389/fmicb.2018.02 414.
［30］	Huang R, Ning H, Shen M, et al. Probiotics for the treatment of atopic dermatitis in children: a systematic review and meta⁃analysis of randomized controlled trials［J］. Front Cell Infect Microbiol, 2017,7:392. doi: 10.3389/fcimb.2017.00392.
［31］	Kim SO, Ah YM, Yu YM, et al. Effects of probiotics for the treatment of atopic dermatitis: a meta⁃analysis of randomized controlled trials［J］. Ann Allergy Asthma Immunol, 2014,113（2）:217⁃226. doi: 10.1016/j.anai.2014.05.021.
［32］	Cabana MD, McKean M, Caughey AB, et al. Early probiotic supplementation for eczema and asthma prevention: a randomized controlled trial［J］. Pediatrics, 2017,140（3）. pii: e20163000. doi: 10.1542/peds.2016⁃3000.
［33］	Rather IA, Bajpai VK, Kumar S, et al. Probiotics and atopic dermatitis: an overview［J］. Front Microbiol, 2016,7:507. doi: 10.3389/fmicb.2016.00507.
［34］	Meisel JS, Sfyroera G, Bartow⁃McKenney C, et al. Commensal microbiota modulate gene expression in the skin［J］. Microbiome, 2018,6（1）:20. doi: 10.1186/s40168⁃018⁃0404⁃9.

宏基因组学在特应性皮炎研究中的应用进展

Application of metagenomics in atopic dermatitis

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