我国特应性皮炎流行病学调查

摘要/Abstract

摘要： 目的了解我国青少年特应性皮炎的发病情况。方法对我国不同地区6～20岁年龄段的学生进行问卷调查。结果调查共涉及11个省市的22个调查点,人口总数78586人。发现特应性皮炎患者548例,其中男347例,女201例,总标化患病率为0.69%,男性标化患病率为0.84%,女性标化患病率为0.51%,两者间差异有显著性(P<0.01)。城市标化患病率为1.10%,农村为0.73%,经检验差异有显著性(P<0.01)。南、中、北部特应性皮炎的患病率经标化后,分别为0.31%、0.79%和0.56%,三者间比较差异有显著性。患病率随年龄增长而呈下降趋势,经相关分析,r=-0.78,P<0.05。结论 1998年11、12月我国22个调查点6～20岁年龄段中小学生特应性皮炎的时点患病率经标化后,表现为城市高于农村,男性高于女性,且患病率与年龄呈负相关。

关键词: 皮炎, 特应性, 患病率

Abstract: Objective To study the prevalence of atopic dermatitis (AD) in China. Method School children aged 6～20 were surveyed with questionnaire in different areas in our country. Results This survey was carried out in 22 cities and rural areas, distributed in 11 provinces. There were 548 AD patients(347 males and 201 females) in a total population of 78 586. The total standardized prevalence (SP) was 0.69%. The SPs of the males and the females were 0.84% and 0.51%, respectively, the difference being statistically significant(P<0.01). The SPs were significantly different between urban(1.10%) and rural areas(0.73%)(P<0.01). The significant difference of SPs was also found in the South (0.31%), Middle (0.79%) and North China (0.56%). The prevalence of AD correlated negatively with the age (r=-0.78, P<0.05). Conclusion It is indicated that standardized prevalences of AD are higher in the urban than those in the rural areas, and in the males than those in the females in our survey in November and December of 1998. The prevalence of AD correlates negatively with the age.

Key words: Dermatitis, atopic, Prevalence

顾恒, 颜艳, 陈崑, 陈祥生, 曹宁校, 邵长庚, 叶干运. 我国特应性皮炎流行病学调查[J]. 中华皮肤科杂志, 2000, 33(6): 379-382.doi:

GU Heng, YAN Yan, CHEN Kun. Survey on Atopic Dermatitis in China[J]. Chinese Journal of Dermatology, 2000, 33(6): 379-382.doi:

参考文献

1 田润梅,康克非,余碧娥,等.4306名中小学生遗传过敏性皮炎的调查.中华皮肤科杂志,1992,25:183-184.
2 Worldwide variation in prevalence of symptoms of asthma,allergic rhino-conjunctivitis, and atopic eczema: ISAAC. The International Study of Asthma and Allergies in Childhood (ISAAC) Steering Committee. Lancet, 1998,351:1225-1232.
3 Williams HC, Burney PG, Pembroke AC, et al. Validation of the U.K.diagnostic criteria for atopic dermatitis in a population setting. U.K. Diagnostic Criteria for Atopic Dermatitis Working Party. Br J Dermatol, 1996,135:12-17.
4 顾恒,陈祥生,陈,等.特应性皮炎诊断标准的评价.中华皮肤科杂志,2000,33:222-226.
5 国家统计局人口与就业统计司.中国人口统计年鉴(1997年).北京.中国统计出版社,1997.
6 顾恒,颜艳,陈,等.南京市2249名中小学生异位性皮炎调查分析.中国麻风皮肤病杂志,1999,15:153-155.
7 Neame RL, Berth-Jones J, Kurinczuk JJ, et al. Prevalence of atopic dermatitis in Leicester: a study of methodology and examination of possible ethnic variation. Br J Dermatol, 1995,132:772-777.
8 Jaafar RB, Pettit JH. Atopic eczema in a multiracial country(Malaysia). Clin Exp Dermatol,1993,18:496-499.
9 Williams HC, Pembroke AC, Forsdyke H, et al. London-born black Caribbean children are at increased risk of atopic dermatitis. J Am Acad Dermatol,1995,32:212-217.
10 Sladden MJ, Dure-Smith B, Berth-Jones J, et al. Ethnic differences in the pattern of skin disease seen in a dermatology department-atopic dermatitis is more common among Asian referrals in Leicestershire. Clin Exp Dermatol,1991,16:348-349.
11 Robertson CF, Heycock E, Bishop J, et al. Prevalence of asthma in Melbourne school children: changes over 26 years. BMJ,1991,302:1116-1118.
12 Tomita C, Tanaka Y, Ishii N, et al. Atopic dermatitis and related factors observed at infant physical examination at health centers. Nippon Koshu Eisei Zasshi, 1997,44:384-390.
13 Schafer T, Dirschedl P, Kunz B, et al. Maternal smoking during pregnancy and lactation increases the risk for atopic eczema in the offspring. J Am Acad Dermatol,1997,36: 550-556.
14 全国银屑病流行调查组.全国1984年银屑病流行调查报告.中华皮肤科杂志,1986,19:253-2611.

[1]	梁源刘玲玲王珊赵作涛马琳向欣顾恒陈崑王华易红陈谨萍张金桃姚志荣郭一峰陈戟程颖朱学骏. 0.03%他克莫司软膏长期间歇维持治疗儿童特应性皮炎的多中心随机对照临床研究[J]. 中华皮肤科杂志, 2019, 52(8): 519-524.
[2]	路坦王珊王榴慧李萍舒虹申春平吴瑶罗珍缪丽敏王红兵焦磊田晶彭晓霞赵牧童刘盈聂晓璐马琳何黎. 一种含青刺果油等提取物的润肤剂改善儿童特应性皮炎缓解期临床症状的多中心、随机、平行对照临床研究[J]. 中华皮肤科杂志, 2019, 52(8): 537-541.
[3]	李凌佳刘彤云. 胱天蛋白酶14在慢性光化性皮炎患者皮损中的表达及中波紫外线对其mRNA和蛋白在HaCaT细胞中表达的影响[J]. 中华皮肤科杂志, 2019, 52(7): 486-490.
[4]	张宇韩悦徐蓓蕾凌诗琪罗阳刘笑纯姚煦. 卵清蛋白联合卡泊三醇诱导构建特应性皮炎小鼠模型[J]. 中华皮肤科杂志, 2019, 52(7): 481-485.
[5]	中国医师协会皮肤科医师分会规范化诊疗工作委员会中国医学装备协会皮肤病与皮肤美容专业委员会皮肤外科装备学组和皮肤光治疗学组. 窄谱中波紫外线家庭光疗临床应用专家共识[J]. 中华皮肤科杂志, 2019, 52(3): 156-161.
[6]	王刚. 皮肤科生物制剂的主要不良反应及对策[J]. 中华皮肤科杂志, 2019, 52(2): 77-80.
[7]	胡宇晴张建中. 特应性皮炎治疗药物研究进展[J]. 中华皮肤科杂志, 2019, 52(1): 57-60.
[8]	张南王莲刘莲张自晖蒋献. 特应性皮炎相关细胞因子对皮肤屏障的影响[J]. 中华皮肤科杂志, 2019, 52(1): 46-49.
[9]	申春平王华王榴慧肖媛媛马琳. 地奈德乳膏与丁酸氢化可的松乳膏治疗婴幼儿特应性皮炎的多中心、随机、平行对照临床研究[J]. 中华皮肤科杂志, 2019, 52(1): 11-15.
[10]	邬鑫鑫童中胜段逸群. 白色划痕征在特应性皮炎中的特异性及其持续时间与疾病严重程度的相关性[J]. 中华皮肤科杂志, 2019, 0(0): 20180773-20180773.
[11]	罗瑞静刘杰彭勇王英杰武宗琴姜珠倩李淑柴维汉李斌. 特应性皮炎患儿与正常儿童肠道菌群差异性研究[J]. 中华皮肤科杂志, 2019, 0(0): 20180738-20180738.
[12]	温禾姚煦. 外用益生菌在防治特应性皮炎中的应用[J]. 中华皮肤科杂志, 2018, 51(9): 707-709.
[13]	邓琪曲才杰毕健平. 斑块型间质性肉芽肿性皮炎一例[J]. 中华皮肤科杂志, 2018, 51(8): 620-620.
[14]	王俊霞杨子微单士军车雅敏陈洪铎. 薏苡仁提取物对BALB/c小鼠特应性皮炎模型的疗效观察及机制探讨[J]. 中华皮肤科杂志, 2018, 51(8): 609-613.
[15]	邹娟娟姚琳谭雪晶韩世新周梅娟. 英夫利西单抗治疗泛发型连续性肢端皮炎一例[J]. 中华皮肤科杂志, 2018, 51(8): 617-618.