中华皮肤科杂志 ›› 2005, Vol. 38 ›› Issue (9): 540-542.

• 论著 • 上一篇    下一篇

阿维A治疗前后对银屑病患者血管内皮生长因子表达的影响

温炬1, 罗权2, 张锡宝2, 林中方1   

  1. 1. 广东省第二人民医院皮肤性病科, 广州510317;
    2. 广州市皮肤病防治研究所
  • 收稿日期:2004-10-14 发布日期:2005-09-15
  • 基金资助:
    广东省重点科技攻关项目(99050)广东省医学科研项目(A2004515)

Effects of Acitretin on Angiogenesis induced by Vascular Endothelial Growth Factor (VEGF) in Patients with Psoriasis

WEN Ju1, LUO Quan2, ZHANG Xi-bao2, LIN Zhong-fang1   

  1. Department of Dermatology, the Second People's Hospital of Guangdong Province, Guangzhou 510317, China
  • Received:2004-10-14 Published:2005-09-15

PDF

155

赞

摘要： 目的 研究阿维A对血管内皮生长因子(VEGF)促银屑病血管生成的调节作用,探讨阿维A治疗银屑病的机制。方法 免疫组化法检测32例银屑病患者经阿维A治疗前后皮损的微血管密度和VEGF蛋白的表达情况。应用双抗体夹心酶联免疫吸附法(ELISA)检测32例银屑病患者经阿维A治疗前后外周血清中VEGF水平。结果 ①银屑病患者经阿维A治疗前皮损VEGF蛋白的表达及微血管密度值显著高于治疗后(P<0.05)和正常人对照组(P<0.001)。②银屑病患者阿维A治疗前的血清VEGF水平高于治疗后(P<0.001)及正常人对照组(P<0.001)。结论 VEGF在银屑病新生血管生成中起重要作用。阿维A可能通过抗新生血管生成的作用来治疗银屑病。

关键词: 阿维A, 银屑病, 内皮生长因子, 新生血管化, 病理性, 微血管密度

Abstract: Objective To investigate the mechanism of effects of acitretin on the treatment of psoriasis. Methods The expression of vascular endothelial growth factor (VEGF) and micro-vascular density (MVD) were detected by immunohistochemical technique before and after treatment with acitretin in 32 patients with psoriasis. Serum level of VEGF was measured by double antibody sandwich enzyme-linked immunosorbent assay (ELISA). Results The expression of VEGF protein and MVD were significantly higher in psoriatic lesions before treatment with acitretin than those after treatment (P<0.05) and those in the normal controls (P<0.001). Conclusions VEGF plays an important role in the angiogenesis of psoriasis, which indicates that anti-angiogenesis may be involved in the mechanism of effects of acitretin on the treatment of psoriasis.

Key words: Acitretin, Psoriasis, Endothelial growth factors, Neovascularization, pathologic, Micro-vascular density