中华皮肤科杂志 ›› 2002, Vol. 35 ›› Issue (5): 386-388.

• 论著 • 上一篇    下一篇

维生素D受体基因多态性与银屑病的关系

朱慧琴1, 谢匡成2, 陈玲娣1, 朱光斗1   

  1. 1. 上海市第一人民医院皮肤科, 200080;
    2. 上海市第一人民医院中心实验室, 200080
  • 收稿日期:2001-09-13 出版日期:2002-10-15 发布日期:2002-10-15
  • 基金资助:
    中华医学会皮肤科学会科研基金资助课题(2000年度杨森基金)

The Association between Vitamin D Receptor Polymorphism and Psoriasis

ZHU Huiqin1, XIE Kuangcheng2, CHEN Lingdi1, ZHU Guangdou1   

  1. Department of Dermatology, Shanghai First People's Hospital, Shanghai 200080, China
  • Received:2001-09-13 Online:2002-10-15 Published:2002-10-15

PDF (PC)

133

赞

摘要： 目的 探讨维生素D受体(VDR)基因多态性与银屑病的关系。方法 采用聚合酶链反应和限制性片段长度多态性(PCR-RFLP),对112例无血缘关系的银屑病患者和108例无血缘关系的健康人员的VDR基因型进行分析。结果 AA、Bb基因型在健康人中出现的频率仅7.4%及14.8%,而在银屑病人中出现的频率为19.6%及32.1%.进一步分析VDR基因型与银屑病患者性别、发病年龄、家族史等的关系,未发现显着相关。在统计等位基因A、a和B、b时,发现它们在两组人群中出现的频率差异均无显着性。结论 维生素D受体(VDR)基因型分布在银屑病患者与健康人中是显着不同的,纯合子AA基因型或杂合子Bb基因型的出现可能增加患银屑病的易患性。

关键词: 银屑病, 受体,骨化三醇, 多态现象(遗传学)

Abstract: Objective To study the correlation between vitamin D receptor(VDR)polymorphism and psoriasis in the Chinese patients.Methods VDR genotypes were determined by PCR-RFLP in 112 unrelated psoriatic patients as well as 108 unrelated healthy controls.Results AA and Bb genotypes were found to be expressed more frequently in psoriatic patients(19.6% and 32.1%)than those in normal controls(7.4% and 14.8%),respectively.However,no signifi cant correlation was identified between VDR polymorphismand sex,age at onset,family history of psoriasis in psoriatic patients.In addition,there was no significant difference in the frequency of A,a alleles and B,b alleles between normal controls and psoriatic patients.Conclusions There is a significant difference in VDR genotypes between psoriatic patients and normal controls.The presence of hom ozygote AA or heterozygote Bb might contribute to the susceptibility of psoriasis.

Key words: Psoriasis, Receptors,calcipotriol, Polymorphism(Genetics)