中华皮肤科杂志 ›› 2002, Vol. 35 ›› Issue (5): 383-385.

• 论著 • 上一篇    下一篇

寻常型银屑病患者皮损中维A酸受体mRNA的表达

冯素英, 林麟, 吴勤学, 周武庆   

  1. 中国医学科学院、中国协和医科大学皮肤病研究所, 南京210042
  • 收稿日期:2001-12-05 出版日期:2002-10-15 发布日期:2002-10-15
  • 基金资助:
    人事部留学回国人员基金

Expression of RARγ/RXRαmRNA in Patients with Psoriasis Vulgaris

FENG Suying, LIN lin, WU Qinxue, ZHOU Wuqing   

  1. Institute of Dermatology, Chinese Academy of Medical Sciences&Peking Union Medical College, Nanjing 210042, China
  • Received:2001-12-05 Online:2002-10-15 Published:2002-10-15

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摘要： 目的 探讨维A酸受体(RARγ/RXRα)mRNA在寻常型银屑病患者皮损中的表达。方法 应用RT-PCR方法检测20例寻常型银屑病患者皮损部位和10例正常人表皮中RARγ/RXRαmRNA的表达。结果 在寻常型银屑病患者皮损中,RXRαmRNA的表达水平为0.1976±0.0933,较正常对照组低(正常对照组为0.5867±0.0132),在统计学上差异有显着性(P<0.01);RARγmRNA在银屑病患者和正常人表皮中的表达水平分别为0.5037±0.0883和0.5624±0.0767,两者差异无显着性。结论 RXRαmRNA表达水平的降低可能和银屑病的发病有关。

关键词: 受体,维甲酸, 银屑病

Abstract: Objective To study the level of expression of RARγ/RXRαmRNA in skin lesions of patients with psoriasis vulgaris.Methods The skin biopsies were collected from skin lesions in 20 cases of psoriasis vulgaris and 10 normal controls.Expression of RARγ/RXRαmRNA was detected by RT-PCR.Results Expression levels of RXRαmRNA were 0.19760±0.0933in epidermides from psoriatic lesions,which were markedly lower than those in normal controls(0.5867±0.0132)(P<0.01).Expression levels of RARγmRNA were 0.5037±0.0883 and 0.5624±0.0767,respectvely,without significant difference(P>0.05).Conclusion The results indicate that decreased expression of RXRαmRNA might be related to the pathogenesis of psoriasis.

Key words: Receptors,retinoic acid, Psoriasis