细胞铁死亡参与白癜风发病机制与相关治疗药物研究进展

doi:10.35541/cjd.20240095

中华皮肤科杂志 ›› 2025, Vol. 58 ›› Issue (9): 886-889.doi: 10.35541/cjd.20240095

细胞铁死亡参与白癜风发病机制与相关治疗药物研究进展

徐煦清¹ 胡雯² 康晓静²

¹新疆医科大学研究生学院，乌鲁木齐 830001；²新疆维吾尔自治区人民医院皮肤性病科新疆皮肤性病临床医学研究中心新疆皮肤病研究重点实验室，乌鲁木齐 830001

收稿日期:2024-02-22 修回日期:2025-03-16 发布日期:2025-09-01
通讯作者: 康晓静 E-mail:drkangxj666@163.com
基金资助:
新疆维吾尔自治区“天山英才”培养计划（2022TSYCLJ0025）；国家自然科学基金（82173406）；新疆维吾尔自治区重点研发计划项目（2024B03039-1、2024B03039-2）

Cell ferroptosis in the pathogenesis of vitiligo and advances in related therapeutic agents

Xu Xuqing¹, Hu Wen², Kang Xiaojing²

¹Graduate School of Xinjiang Medical University, Urumqi 830001, China; ²Department of Dermatology and Venereology, People′s Hospital of Xinjiang Uygur Autonomous Region, Xinjiang Clinical Research Center for Dermatology and Venereology, Xinjiang Key Laboratory of Dermatology Research, Urumqi 830001, China

Received:2024-02-22 Revised:2025-03-16 Published:2025-09-01
Contact: Kang Xiaojing E-mail:drkangxj666@163.com
Supported by:
Xinjiang Uygur Autonomous Region Tianshan Talent Training Program （2022TSYCLJ0025）; National Natural Science Foundation of China （82173406）; Xinjiang Uygur Autonomous Region Key R & D Program （2024B03039-1, 2024B03039-2）

摘要/Abstract

摘要： 【摘要】黑素细胞死亡是白癜风最显著的特征，铁死亡是独特的程序性细胞死亡方式，以铁依赖性致死性脂质活性氧积累为主要特征。最新研究显示，铁死亡参与白癜风发生发展中黑素细胞的损伤。本文综述铁死亡在白癜风中可能的作用机制及相关治疗药物，旨在为探索白癜风发病机制、潜在治疗靶点和相关靶向治疗药物提供新思路。

关键词: 白癜风, 铁死亡, 活性氧, 脂质过氧化作用, 氧化应激, 药物

Abstract: 【Abstract】 Melanocyte death is the most notable feature of vitiligo, and ferroptosis is a unique pattern of programmed cell death, characterized by the iron-dependent accumulation of lethal lipid reactive oxygen species. Recent studies have found that ferroptosis is involved in the damage to melanocytes in the development of vitiligo. This review summarizes the possible mechanisms of ferroptosis in vitiligo and related therapeutic agents, aiming to provide novel insights into the pathogenesis of vitiligo, potential therapeutic targets, and associated targeted therapies.

Key words: Vitiligo, Ferroptosis, Reactive oxygen species, Lipid peroxidation, Oxidative stress, Drugs

徐煦清胡雯康晓静. 细胞铁死亡参与白癜风发病机制与相关治疗药物研究进展[J]. 中华皮肤科杂志, 2025,58(9):886-889. doi:10.35541/cjd.20240095

Xu Xuqing, Hu Wen, Kang Xiaojing. Cell ferroptosis in the pathogenesis of vitiligo and advances in related therapeutic agents[J]. Chinese Journal of Dermatology, 2025, 58(9): 886-889.doi:10.35541/cjd.20240095

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细胞铁死亡参与白癜风发病机制与相关治疗药物研究进展

Cell ferroptosis in the pathogenesis of vitiligo and advances in related therapeutic agents

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