中华皮肤科杂志 ›› 2025, Vol. 58 ›› Issue (7): 583-590.doi: 10.35541/cjd.20250092

• 指南与共识·毛发疾病 • 上一篇    下一篇

毛发扁平苔藓/前额纤维化性秃发诊疗中国专家共识(2025版)

中华医学会皮肤性病学分会毛发学组   

  1. 中华医学会皮肤性病学分会毛发学组
  • 收稿日期:2025-02-24 修回日期:2025-05-12 发布日期:2025-07-03
  • 通讯作者: 吴文育;周城 E-mail:wenyu_wu@fudan.edu.cn; chengzhou@live.cn
  • 基金资助:
    国家自然科学基金(82373504);国家重点研发计划(2023YFC2509000);上海市重中之重研究中心建设项目(2023ZZ02018);上海申康医院发展中心临床研究计划(SHDC22022302、SHDC12024144);上海毛发医学工程技术研究中心项目(19DZ2250500)

Chinese expert consensus on the diagnosis and treatment of lichen planopilaris/frontal fibrosing alopecia (2025 edition)

Hair Research Group, Chinese Society of Dermatology   

  1. Hair Research Group, Chinese Society of Dermatology
  • Received:2025-02-24 Revised:2025-05-12 Published:2025-07-03
  • Contact: Wu Wenyu; Zhou Cheng E-mail:wenyu_wu@fudan.edu.cn; chengzhou@live.cn
  • Supported by:
    National Natural Science Foundation of China (82373504); National Key Research and Development Program of China (2023YFC2509000); Key Specialty Research Centre of Shanghai Health Commission (2023ZZ02018); Clinical Research Plan of Shanghai Hospital Development Center Foundation (SHDC22022302, SHDC12024144); Shanghai Engineering Research Center of Hair Medicine (19DZ2250500)

摘要: 【摘要】 毛发扁平苔藓(LPP)和前额纤维化性秃发(FFA)是临床最常见的两种原发性淋巴细胞性瘢痕性秃发,其治疗极具挑战性。这组疾病以纤维组织取代毛囊皮脂腺单位为特征,致毛囊被不可逆转地破坏,最终造成毛囊瘢痕化。近年来,随着对这两种疾病的深入研究,在传统局部外用药、系统口服药物等治疗手段的基础上,局部和外用的新型小分子药物如Janus激酶抑制剂,也为治疗提供了新的选择。中华医学会皮肤性病学分会毛发学组在国内外最新共识的基础上,结合我国的诊疗现状,针对LPP和FFA的病因、发病机制、临床表现、辅助检查、诊断、鉴别诊断及治疗等方面进行充分讨论后形成共识,旨在进一步规范这两种疾病的临床诊疗并提供更为科学、权威的参考依据。

关键词: 秃发, 原发性瘢痕性秃发, 毛发扁平苔藓, 前额纤维化性秃发, 诊断, 治疗, 共识

Abstract: 【Abstract】 Lichen planopilaris (LPP) and frontal fibrosing alopecia (FFA) are the two most common types of primary lymphocytic cicatricial alopecia in clinical practice, but their treatment poses significant challenges. These conditions are characterized by the replacement of hair follicle-sebaceous gland units with fibrous tissues, leading to irreversible destruction of hair follicles and ultimately resulting in scarring of the follicles. In recent years, with a deepened understanding of these two diseases, new treatment options have emerged in addition to traditional topical medications and systemic oral drugs, including novel topical small molecule drugs such as Janus kinase inhibitors. Based on the latest Chinese and international consensus as well as current clinical practice in China, the Hair Research Group of Chinese Society of Dermatology organized experts to develop a consensus on the etiology, pathogenesis, clinical manifestations, auxiliary examinations, diagnosis, differential diagnosis, and treatment of LPP and FFA after thorough discussions, aiming to further standardize the clinical diagnosis and treatment of these two conditions and provide a more scientific and authoritative reference.

Key words: Alopecia, Primary cicatricial alopecia, Lichen planopilaris, Frontal fibrosing alopecia, Diagnosis, Therapy, Consensus

引用本文

中华医学会皮肤性病学分会毛发学组. 毛发扁平苔藓/前额纤维化性秃发诊疗中国专家共识(2025版)[J]. 中华皮肤科杂志, 2025,58(7):583-590. doi:10.35541/cjd.20250092

Hair Research Group, Chinese Society of Dermatology. Chinese expert consensus on the diagnosis and treatment of lichen planopilaris/frontal fibrosing alopecia (2025 edition)[J]. Chinese Journal of Dermatology, 2025, 58(7): 583-590.doi:10.35541/cjd.20250092