巨噬细胞在瘢痕疙瘩发病机制及治疗中的研究进展

doi:10.35541/cjd.20240090

中华皮肤科杂志 ›› 2024, e20240090.doi: 10.35541/cjd.20240090

巨噬细胞在瘢痕疙瘩发病机制及治疗中的研究进展

赵莹¹ 杨勇² 王焱³ 魏琴⁴ 王烨涛⁴

¹北京协和医学院中国医学科学院皮肤病医院皮肤病研究所，南京 210000；²中国医学科学院北京协和医学院皮肤病医院遗传病中心，南京 210000；³中国医学科学院北京协和医学院皮肤病医院皮肤外科，南京 210000；⁴中国医学科学院北京协和医学院皮肤病医院中心实验室，南京 210000

收稿日期:2024-02-19 修回日期:2024-07-29 发布日期:2024-08-28
通讯作者: 王烨涛 E-mail:yetaowang@163.com
基金资助:
中国医学科学院皮肤病医院高层次人才专项经费（3301030103119）；中国医学科学院医学与健康科技创新工程项目（2021-I2M-1-018）

Role of macrophages in the pathogenesis and treatment of keloids

Zhao Ying¹, Yang Yong², Wang Yan³, Wei Qin⁴, Wang Yetao⁴

¹Hospital for Skin Diseases, Institute of Dermatology, Chinese Academy of Medical Sciences ＆ Peking Union Medical College, Nanjing 210000, China; ²Genetic Skin Disease Center, Hospital of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing 210042, China; ³Department of Dermatologic Surgery, Hospital of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing 210042, China; ⁴Central Laboratory, Hospital of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing 210042, China

Received:2024-02-19 Revised:2024-07-29 Published:2024-08-28
Contact: Wang Yetao E-mail:yetaowang@163.com
Supported by:
Special Funding for High-level Talents of Hospital of Dermatology, Chinese Academy of Medical Sciences （3301030103119）; CAMS Innovation Fund for Medical Sciences （2021-I2M-1-018）

摘要/Abstract

摘要： 【摘要】瘢痕疙瘩是一种异常纤维增生性皮肤病，复发性高且缺乏临床有效治疗方案。目前发病机制尚未明确，已有研究表明巨噬细胞在瘢痕疙瘩进程中发挥重要作用。本文根据巨噬细胞在瘢痕疙瘩中的极化、作用机制、细胞相互作用、针对性治疗方案阐述巨噬细胞在瘢痕疙瘩发病机制中的重要性，旨在为瘢痕疙瘩的研究和治疗提供参考。

关键词: 瘢痕疙瘩, 巨噬细胞, 转化生长因子β, 极化, 细胞外基质

Abstract: 【Abstract】 Keloid is an abnormal fibroproliferative skin disease characterized by high recurrence rates and lack of clinically effective treatments. Currently, the pathogenesis of keloids is not yet clear, but accumulated evidence has indicated that macrophages play important roles in the progression of keloids. This review summarizes the polarization, mechanisms of action, and cellular crosstalk of macrophages in the pathogenesis of keloids, as well as macrophage-targeted therapies for keloids, aiming to provide new insights for the research and treatment of keloids.

Key words: Keloid, Macrophages, Transforming growth factor beta, Polarization, Extracellular matrix

赵莹杨勇王焱魏琴王烨涛. 巨噬细胞在瘢痕疙瘩发病机制及治疗中的研究进展[J]. 中华皮肤科杂志, 2024,e20240090. doi:10.35541/cjd.20240090

Zhao Ying, Yang Yong, Wang Yan, Wei Qin, Wang Yetao. Role of macrophages in the pathogenesis and treatment of keloids[J]. Chinese Journal of Dermatology,2024,e20240090. doi:10.35541/cjd.20240090

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巨噬细胞在瘢痕疙瘩发病机制及治疗中的研究进展

Role of macrophages in the pathogenesis and treatment of keloids

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