| ［1］ |
Kumar M, Duraisamy K, Chow BK. Unlocking the non⁃IgE⁃mediated pseudo⁃allergic reaction puzzle with Mas⁃related G⁃protein coupled receptor member X2 （MRGPRX2）［J］. Cells, 2021,10（5）:1033. doi: 10.3390/cells10051033.
|
| ［2］ |
Young D, Waitches G, Birchmeier C, et al. Isolation and characterization of a new cellular oncogene encoding a protein with multiple potential transmembrane domains［J］. Cell, 1986,45（5）:711⁃719. doi: 10.1016/0092⁃8674（86）90785⁃3.
|
| ［3］ |
Inclan⁃Rico JM, Kim BS, Abdus⁃Saboor I. Beyond somatosensation: Mrgprs in mucosal tissues［J］. Neurosci Lett, 2021,748:135689. doi: 10.1016/j.neulet.2021.135689.
|
| ［4］ |
Wang Z, Franke K, Bal G, et al. MRGPRX2⁃mediated degranulation of human skin mast cells requires the operation of G（αi）, G（αq）, Ca++ channels, ERK1/2 and PI3K⁃interconnection between early and late signaling［J］. Cells, 2022,11（6）:953. doi: 10.3390/cells11060953.
|
| ［5］ |
Babina M, Wang Z, Roy S, et al. MRGPRX2 is the codeine receptor of human skin mast cells: desensitization through β⁃arrestin and lack of correlation with the FcεRⅠ pathway［J］. J Invest Dermatol, 2021,141（5）:1286⁃1296. doi: 10.1016/j.jid. 2020.09.017.
|
| ［6］ |
Chompunud Na Ayudhya C, Amponnawarat A, Ali H. Substance P serves as a balanced agonist for MRGPRX2 and a single tyrosine residue is required for β⁃arrestin recruitment and receptor internalization［J］. Int J Mol Sci, 2021,22（10）:5318. doi: 10.3390/ijms22105318.
|
| ［7］ |
Che D, Zheng Y, Hou Y, et al. Action of substance P and PAMP（9⁃20） on different excitation sites of MRGPRX2 induces differences in mast cell activation［J］. Int Immunopharmacol, 2021,101（Pt B）:108342. doi: 10.1016/j.intimp.2021.108342.
|
| ［8］ |
Ogasawara H, Noguchi M. Therapeutic potential of MRGPRX2 inhibitors on mast cells［J］. Cells, 2021,10（11）:2906. doi: 10. 3390/cells10112906.
|
| ［9］ |
Fujisawa D, Kashiwakura J, Kita H, et al. Expression of Mas⁃related gene X2 on mast cells is upregulated in the skin of patients with severe chronic urticaria［J］. J Allergy Clin Immunol, 2014,134（3）:622⁃633.e9. doi: 10.1016/j.jaci.2014.05.004.
|
| ［10］ |
Fadaee J, Khoshkhui M, Emadzadeh M, et al. Evaluation of serum substance P level in chronic urticaria and correlation with disease severity［J］. Iran J Allergy Asthma Immunol, 2020,19（1）:18⁃26. doi: 10.18502/ijaai.v19i1.2414.
|
| ［11］ |
Cao T, Cha HY, Yang EM, et al. Elevated MRGPRX2 levels related to disease severity in patients with chronic spontaneous urticaria［J］. Allergy Asthma Immunol Res, 2021,13（3）:498⁃506. doi: 10.4168/aair.2021.13.3.498.
|
| ［12］ |
Shtessel M, Limjunyawong N, Oliver ET, et al. MRGPRX2 activation causes increased skin reactivity in patients with chronic spontaneous urticaria［J］. J Invest Dermatol, 2021,141（3）:678⁃681.e2. doi: 10.1016/j.jid.2020.06.030.
|
| ［13］ |
Nishimori N, Toyoshima S, Sasaki⁃Sakamoto T, et al. Serum level of hemokinin⁃1 is significantly lower in patients with chronic spontaneous urticaria than in healthy subjects［J］. Allergol Int, 2021,70（4）:480⁃488. doi: 10.1016/j.alit.2021.05.002.
|
| ［14］ |
Wang Z, Babina M. MRGPRX2 signals its importance in cutaneous mast cell biology: does MRGPRX2 connect mast cells and atopic dermatitis?［J］. Exp Dermatol, 2020,29（11）:1104⁃1111. doi: 10.1111/exd.14182.
|
| ［15］ |
Serhan N, Basso L, Sibilano R, et al. House dust mites activate nociceptor⁃mast cell clusters to drive type 2 skin inflammation［J］. Nat Immunol, 2019,20（11）:1435⁃1443. doi: 10.1038/s41590⁃019⁃0493⁃z.
|
| ［16］ |
Babina M, Wang Z, Franke K, et al. Thymic stromal lymphopoietin promotes MRGPRX2⁃triggered degranulation of skin mast cells in a STAT5⁃dependent manner with further support from JNK［J］. Cells, 2021,10（1）:102. doi: 10.3390/cells10010102.
|
| ［17］ |
Jia T, Che D, Zheng Y, et al. Mast cells initiate type 2 inflammation through tryptase released by MRGPRX2/MRGPRB2 activation in atopic dermatitis［J］. J Invest Dermatol, 2024,144（1）:53⁃62.e2. doi: 10.1016/j.jid.2023.06.201.
|
| ［18］ |
Redhu D, Franke K, Aparicio⁃Soto M, et al. Mast cells instruct keratinocytes to produce thymic stromal lymphopoietin: relevance of the tryptase/protease⁃activated receptor 2 axis［J］. J Allergy Clin Immunol, 2022,149（6）:2053⁃2061.e6. doi: 10.1016/j.jaci.2022.01.029.
|
| ［19］ |
Meixiong J, Anderson M, Limjunyawong N, et al. Activation of mast⁃cell⁃expressed Mas⁃related G⁃protein⁃coupled receptors drives non⁃histaminergic itch［J］. Immunity, 2019,50（5）:1163⁃1171.e5. doi: 10.1016/j.immuni.2019.03.013.
|
| ［20］ |
Larsen EG, Cho TS, McBride ML, et al. Transmembrane protein TMEM184B is necessary for interleukin⁃31⁃induced itch［J］. Pain, 2022,163（5）:e642⁃e653. doi: 10.1097/j.pain.00000000 00002452.
|
| ［21］ |
Yoshida K, Tanihara S, Miyashita Y, et al. P2X4 receptor stimulation enhances MrgprB2⁃mediated mast cell activation and pseudoallergic reactions in mice［J］. Sci Rep, 2022,12（1）:18613. doi: 10.1038/s41598⁃022⁃21667⁃6.
|
| ［22］ |
Suzuki Y, Liu S, Kadoya F, et al. Association between mutated Mas⁃related G⁃protein⁃coupled receptor⁃X2 and rocuronium⁃induced intraoperative anaphylaxis. Comment on Br J Anaesth 2020; 125: e448⁃50［J］. Br J Anaesth, 2021,127（1）:e21⁃e22. doi: 10.1016/j.bja.2021.04.009.
|
| ［23］ |
Chompunud Na Ayudhya C, Amponnawarat A, Roy S, et al. MRGPRX2 activation by rocuronium: insights from studies with human skin mast cells and missense variants［J］. Cells, 2021,10（1）:156. doi: 10.3390/cells10010156.
|
| ［24］ |
McNeil BD, Pundir P, Meeker S, et al. Identification of a mast⁃cell⁃specific receptor crucial for pseudo⁃allergic drug reactions［J］. Nature, 2015,519（7542）:237⁃241. doi: 10.1038/nature14022.
|
| ［25］ |
中华医学会皮肤性病学分会玫瑰痤疮研究中心, 中国医师协会皮肤科医师分会玫瑰痤疮专业委员会. 中国玫瑰痤疮诊疗指南（2021版）［J］. 中华皮肤科杂志, 2021,54（4）:279⁃288. doi: 10.35541/cjd.20201078.
|
| ［26］ |
Chen C, Wang P, Zhang L, et al. Exploring the pathogenesis and mechanism⁃targeted treatments of rosacea: previous understanding and updates［J］. Biomedicines, 2023,11（8）:2153. doi: 10.3390/biomedicines11082153.
|
| ［27］ |
Roy S, Alkanfari I, Chaki S, et al. Role of MrgprB2 in rosacea⁃like inflammation in mice: modulation by β⁃arrestin 2［J］. J Invest Dermatol, 2022,142（11）:2988⁃2997.e3. doi: 10.1016/j.jid.2022.05.005.
|
| ［28］ |
Marek⁃Jozefowicz L, Nedoszytko B, Grochocka M, et al. Molecular mechanisms of neurogenic inflammation of the skin［J］. Int J Mol Sci, 2023,24（5）:5001. doi: 10.3390/ijms2405 5001.
|
| ［29］ |
Azimi E, Reddy VB, Shade KC, et al. Dual action of neurokinin⁃1 antagonists on Mas⁃related GPCRs［J］. JCI Insight, 2016,1（16）:e89362. doi: 10.1172/jci.insight.89362.
|
| ［30］ |
Wang J, Zhang Y, Hu S, et al. Resveratrol inhibits MRGPRX2⁃mediated mast cell activation via Nrf2 pathway［J］. Int Immunopharmacol, 2021,93:107426. doi: 10.1016/j.intimp.2021. 107426.
|
| ［31］ |
Xue Z, Zhang Y, Zeng Y, et al. Licochalcone A inhibits MAS⁃related GPR family member X2⁃induced pseudo⁃allergic reaction by suppressing nuclear migration of nuclear factor⁃κB［J］. Phytother Res, 2021,35（11）:6270⁃6280. doi: 10.1002/ptr.7272.
|
| ［32］ |
Syed M, Kammala AK, Callahan B, et al. Lactic acid suppresses MRGPRX2 mediated mast cell responses［J］. Cell Immunol, 2021,368:104422. doi: 10.1016/j.cellimm.2021.104422.
|
