肠道菌群及短链脂肪酸与慢性自发性荨麻疹相关性研究进展

doi:10.35541/cjd.20230310

中华皮肤科杂志 ›› 2024, e20230310.doi: 10.35541/cjd.20230310

肠道菌群及短链脂肪酸与慢性自发性荨麻疹相关性研究进展

李恩泽¹ 陈璐¹ 张楚翘¹ 姚昱旭¹ 焦晴晴² 季江¹

¹苏州大学附属第二医院皮肤性病科，苏州 215004；²苏州大学附属第一医院皮肤性病科，苏州 215006

收稿日期:2023-06-02 修回日期:2023-11-27 发布日期:2024-02-02
通讯作者: 季江 E-mail:jijiang2222@126.com
基金资助:
国家自然科学基金（82073434）

Correlations of gut microbiota and short-chain fatty acids with chronic spontaneous urticaria

Enze LI¹,Lu CHEN²,Chu-Qiao ZHANG¹, ²,Jiao qingqingJI Jiang

¹Department of Dermatology and Venereology, the Second Affiliated Hospital of Soochow University, Suzhou 215004, Jiangsu, China; ²Department of Dermatology and Venereology, the First Affiliated Hospital of Soochow University, Suzhou 215006, Jiangsu, China

Received:2023-06-02 Revised:2023-11-27 Published:2024-02-02
Contact: Ji Jiang E-mail:jijiang2222@126.com
Supported by:
National Natural Science Foundation of China（82073434）

摘要/Abstract

摘要： 【摘要】慢性自发性荨麻疹与自身免疫及免疫细胞的活化有很大关联，而肠道菌群参与包括调控机体免疫在内的多种生理活动。慢性自发性荨麻疹患者的肠道菌群具有独特的结构组成与代谢特点，肠道菌群失调以及继发的短链脂肪酸缺失可能是疾病发生与炎症加剧的重要原因。已有研究发现，益生菌可以改善荨麻疹患者的临床表现。本文综述肠道菌群及短链脂肪酸与慢性自发性荨麻疹的相关性研究进展。

关键词: 荨麻疹, 慢性自发性荨麻疹, 肠道菌群, 短链脂肪酸

Abstract: 【Abstract】 Autoimmunity and the activation of immune cells are closely related to the occurrence of chronic spontaneous urticaria. while the gut microbiota participates in multiple physiological activities including the regulation of the host′s immunity. Gut microbiota in patients with chronic spontaneous urticaria has unique structural composition and metabolic features. Gut microbiota imbalance and secondary short-chain fatty acid deficiency may be important causes for the occurrence of the disease and aggravation of inflammation. Studies have shown that probiotics can improve the clinical manifestations of patients with urticaria. This review summarizes the research progress in the correlations of gut microbiota and short-chain fatty acids with chronic spontaneous urticaria.

Key words: Urticaria, Chronic spontaneous urticaria, Gut microbiota, Short-chain fatty acids

李恩泽陈璐张楚翘姚昱旭焦晴晴季江. 肠道菌群及短链脂肪酸与慢性自发性荨麻疹相关性研究进展[J]. 中华皮肤科杂志, 2024,e20230310. doi:10.35541/cjd.20230310

Enze LI Lu CHEN Chu-Qiao ZHANG Jiao qingqing JI Jiang. Correlations of gut microbiota and short-chain fatty acids with chronic spontaneous urticaria[J]. Chinese Journal of Dermatology,2024,e20230310. doi:10.35541/cjd.20230310

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肠道菌群及短链脂肪酸与慢性自发性荨麻疹相关性研究进展

Correlations of gut microbiota and short-chain fatty acids with chronic spontaneous urticaria

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