中华皮肤科杂志 ›› 2022, Vol. 55 ›› Issue (8): 665-668.doi: 10.35541/cjd.20210795

• 论著 • 上一篇    下一篇

黏液表皮样癌8例临床及病理分析

陈文静1    邵睿2    邹云敏1    孟中勤1    严翘1    宋琳毅3    孙建方1    陈浩1   

  1. 1中国医学科学院、北京协和医学院皮肤病医院病理科，南京  210042；2江苏大学附属镇江市第一人民医院病理科，镇江  212001；3苏州大学附属第一医院皮肤科，苏州  215000
    陈文静［新疆维吾尔自治区人民医院皮肤性病科  新疆皮肤病临床医学研究中心  新疆皮肤病研究重点实验室（XJYS1707），乌鲁木齐  830001］、邹云敏（无锡市第二人民医院皮肤科，无锡  214000）、孟中勤（郑州大学第一附属医院病理科，郑州  450000）、严翘（东南大学附属中大医院皮肤科，南京  210042）为中国医学科学院、北京协和医学院皮肤病医院病理科进修医生；陈文静和邵睿对本文贡献相同
  • 收稿日期:2021-11-03 修回日期:2022-04-29 发布日期:2022-08-02
  • 通讯作者: 陈浩 E-mail:ch76ch@163.com

Clinical and pathological analysis of 8 cases of mucoepidermoid carcinoma

Chen Wenjing1, Shao Rui2, Zou Yunmin1, Meng Zhongqin1, Yan Qiao1, Song Linyi3, Sun Jianfang1, Chen Hao1   

  1. 1Department of Pathology, Hospital of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing 210042, China; 2Department of Pathology, Zhenjiang First People′s Hospital, Jiangsu University, Zhenjiang 212001, Jiangsu, China; 3Department of Dermatology, The First Affiliated Hospital of Soochow University, Suzhou 215000, Jiangsu, China
    Chen Wenjing （Department of Dermatology and Venereology, People′s Hospital of Xinjiang Uygur Autonomous Region, Xinjiang Clinical Research Center for Dermatologic Diseases, Xinjiang Key Laboratory of Dermatology Research ［XJYS1707］, Urumqi 830001, China）, Zou Yunmin （Department of Dermatology, Wuxi No.2 People′s Hospital, Wuxi 214000, Jiangsu, China）, Meng Zhongqin （Department of Pathology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, China）, Yan Qiao （Department of Dermatology, ZhongDa Hospital, Southeast University, Nanjing 210042, China） are undergoing the refresher training in Department of Pathology, Hospital of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing 210042, China；Chen Wenjing and Shao Rui contributed equally to the article 
  • Received:2021-11-03 Revised:2022-04-29 Published:2022-08-02
  • Contact: Chen Hao E-mail:ch76ch@163.com

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摘要： 【摘要】 目的 探讨黏液表皮样癌的临床、组织病理及鉴别诊断要点。方法 回顾性分析2018—2021年中国医学科学院、北京协和医学院皮肤病医院病理科会诊的8例黏液表皮样癌患者的临床、组织病理、免疫组化、治疗及预后。结果 8例患者中，男5例，女3例，发病年龄19 ~ 67岁，皮损位于唇部黏膜5例、面颊2例、鼻部1例。肿瘤均位于真皮及皮下组织，部分与表皮相连，不同比例的黏液细胞、表皮样细胞、中间细胞排列成巢状、团块状，形成实性或囊性结构，伴有不同程度的导管形成及黏液湖；所有表皮样细胞、中间细胞均表达细胞角蛋白AE1/AE3、CK5/6、P63、癌胚抗原及上皮膜抗原。按照目前国内分级标准，8例中1例为中间级别，其余为低级别。系统检查均未见异常。均接受手术切除治疗，经过12 ~ 36个月随访，无复发及远处转移。结论 黏液表皮样癌临床表现无特征性，诊断主要依靠组织病理学形态；阿辛蓝染色显示黏液细胞胞质内的黏液具有特征性。

关键词: 皮肤肿瘤, 皮肤表现, 病理过程, 黏液表皮样癌

Abstract: 【Abstract】 Objective To investigate clinical and histopathological features and differential diagnostic considerations of mucoepidermoid carcinoma （MEC）. Methods A retrospective study was carried out on clinical manifestations, histopathological and immunohistochemical features, treatment and prognosis of 8 patients with MEC, who were collected from Department of Pathology, Hospital of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College during 2018 - 2021. Results Among the 8 patients, 5 were males and 3 were females, and their age at onset ranged from 19 to 67 years. Skin lesions were located on the lip mucosa in 5 cases, on the cheek in 2 cases, and on the nose in 1 case. Tumors were all located in the dermis and subcutaneous tissue, parts of which were connected to the epidermis; different proportions of mucous cells, epidermoid cells and intermediate cells were arranged in nests or clumps, and formed solid or cystic structures accompanied by varying degrees of formation of ducts and mucus lakes; all epidermoid cells and intermediate cells expressed cytokeratins AE1/AE3, CK5/6, P63, carcinoembryonic antigen and epithelial membrane antigen. According to the current Chinese grading system, 1 of the 8 patients was diagnosed with intermediate-grade MEC, and others were diagnosed with low-grade MEC. No abnormalities were found by systemic examination. All patients received surgical resections. After the follow-up of 12 - 36 months, no recurrence or distant metastasis was observed. Conclusion MEC presents no characteristic clinical manifestations, its diagnosis mainly depends on histopathological features, and mucus in the cytoplasm of mucous cells as shown by alcian blue staining is specific for MEC.

Key words: Skin neoplasms, Skin manifestation, Pathological process, Mucoepidermoid carcinoma