中华皮肤科杂志 ›› 2021, Vol. 54 ›› Issue (10): 915-919.doi: 10.35541/cjd.20191098

• 综述 • 上一篇    下一篇

胸腺基质淋巴细胞生成素在不同皮肤病中的作用机制研究

金欣星    李思哲    左亚刚   

  1. 中国医学科学院、北京协和医学院北京协和医院皮肤科  协和医学转化中心国家皮肤与免疫疾病临床医学研究中心  100730
  • 收稿日期:2019-11-19 修回日期:2020-07-13 发布日期:2021-09-28
  • 通讯作者: 左亚刚 E-mail:zuoyagang@263.net
  • 基金资助:
    国家自然科学基金(81972944);北京市自然科学基金(7192166)

Role of thymic stromal lymphopoietin in various skin diseases

Jin Xinxing, Li Sizhe, Zuo Yagang   

  1. Department of Dermatology, National Clinical Research Center for Skin and Immune Diseases, Translational Medicine Center of Peking Union Medical College Hospital, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China 
  • Received:2019-11-19 Revised:2020-07-13 Published:2021-09-28
  • Contact: Zuo Yagang E-mail:zuoyagang@263.net
  • Supported by:
    National Natural Science Foundation of China(81972944); Beijing Municipal Natural Science Foundation (7192166)

摘要: 【摘要】 胸腺基质淋巴细胞生成素(TSLP)是一种与白细胞介素7(IL-7)类似的细胞因子,可以促进多种细胞的分化和增殖,并使其分泌Th2细胞因子,在机体免疫系统中发挥重要作用。近年来发现在许多皮肤病中TSLP的表达水平异常,在部分皮肤病中其水平高低还与疾病严重程度相关,提示TSLP可能是治疗多种皮肤病的潜在靶点。本文综述近年来TSLP在多种皮肤病(包括炎症性疾病、免疫性疾病、遗传性疾病和肿瘤性疾病)发生发展中的研究进展,为临床相关疾病的诊治提供依据和思路。

关键词: 白细胞介素7, 皮炎, 特应性, 银屑病, 类天疱疮, 大疱性, Netherton综合征, 单纯性大疱性表皮松解症, 皮肤肿瘤, 胸腺基质淋巴细胞生成素

Abstract: 【Abstract】 Thymic stromal lymphopoietin (TSLP), a cytokine similar to interleukin-7 (IL-7), can promote the differentiation and proliferation of a variety of cells, promote the secretion of Th2 cytokines by these cells, and plays an important role in the immune system. In recent years, abnormal expression of TSLP has been found in many skin diseases, and its level is also related to the severity of some skin diseases, suggesting that TSLP may be a potential target for the treatment of various skin diseases. This review summarizes recent research progress in the role of TSLP in the occurrence and development of various skin diseases, including inflammatory diseases, immune diseases, genetic diseases and tumors, and provides a basis and ideas for the diagnosis and treatment of related diseases.

Key words: Interleukin-7, Dermatitis, atopic, Psoriasis, Pemphigoid, bullous, Netherton syndrome, Epidermolysis bullosa simplex, Skin neoplasms, Thymic stromal lymphopoietin