中华皮肤科杂志 ›› 2017, Vol. 50 ›› Issue (9): 670-672.

• 研究报道 • 上一篇    下一篇

近红外光联合他克莫司软膏治疗面部激素依赖性皮炎的随机对照研究

梁津宁1,金外淑2,邵娟2,曲燕2,夏秀娟2   

  1. 1. 烟台毓璜顶医院皮肤科
    2. 烟台毓璜顶医院
  • 收稿日期:2016-08-25 修回日期:2017-01-13 出版日期:2017-09-15 发布日期:2017-08-31
  • 通讯作者: 夏秀娟 E-mail:xiaxiujuan@medmail.com.cn

Near-infrared light combined with tacrolimus ointment for the treatment of facial glucocorticoid-dependent dermatitis: a randomized controlled trial

  • Received:2016-08-25 Revised:2017-01-13 Online:2017-09-15 Published:2017-08-31

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摘要： 目的 探讨近红外光联合0.1%他克莫司软膏治疗面部激素依赖性皮炎的有效性和安全性。方法 2014年12月至2015年12月，在烟台毓璜顶医院皮肤科门诊纳入68例面部激素依赖性皮炎患者，随机数字表法将患者分为联合治疗组和治疗组，每组34例。治疗组给予他克莫司软膏外用，每日2次，4周为1个疗程；联合治疗组在治疗组的基础上给予近红外光治疗，每周1次，共4次。1个疗程结束后评定瘙痒、灼热等临床表现的改善情况以及疗效。结果 联合治疗组有效率85.3%（29/34），治疗组为61.8%（21/34），两组差异有统计学意义（χ2 = 4.84，P < 0.05）。联合治疗组瘙痒和灼热、红斑、鳞屑、丘疹的疗效明显高于治疗组，差异有统计学意义（χ2值分别为4.84、6.35、8.42、5.52，均P＜0.05）。结论 近红外光联合他克莫司软膏治疗面部激素依赖性皮炎安全、有效。

关键词: 皮炎, 激素依赖性

Abstract: Liang Jinning, Jin Waishu, Shao Juan, Qu Yan, Xia Xiujuan Department of Dermatology, Yantai Yuhuangding Hospital, Yantai 264000, Shandong, China Corresponding author: Xia Xiujuan, Email: xiaxiujuan@medmail.com.cn 【Abstract】 Objective To evaluate the efficacy and safety of near-infrared light combined with tacrolimus 0.1% ointment in the treatment of facial glucocorticoid-dependent dermatitis. Methods A total of 68 patients with facial glucocorticoid-dependent dermatitis were enrolled from Department of Dermatology of Yantai Yuhuangding Hospital between December 2014 and December 2015, and randomly and equally divided into treatment group and combination group by a random number table. The treatment group was treated topically with tacrolimus ointment twice a day for 4 weeks. Besides the treatment with tacrolimus ointment, the combination group was irradiated with near-infrared light once a week for 4 sessions. After 4-week treatment, improvement in clinical manifestations such as itching and burning sensation was evaluated, so was the therapeutic effect. Results The combination group showed significantly higher response rate （85.3% ［29/34］） compared with the treatment group （61.8% ［21/34］, χ2 = 4.84, P < 0.05）. Additionally, response rates for itching and burning sensation, erythema, scales and papules were all significantly higher in the combination group than in the treatment group （χ2 = 4.84, 6.35, 8.42 and 5.52, respectively, all P < 0.05）. Conclusion Near-infrared light combined with tacrolimus ointment is effective and safe for the treatment of facial glucocorticoid-dependent dermatitis.