中华皮肤科杂志 ›› 2014, Vol. 47 ›› Issue (12): 894-896.

• 研究报道 • 上一篇    下一篇

CO2点阵激光联合308 nm准分子激光治疗稳定期白癜风的临床观察

孟丽亚1,王逸飞2,张春敏3   

  1. 1. 山东大学第二医院
    2. 山东大学医学院
    3. 山东大学第二医院皮肤科
  • 收稿日期:2014-01-13 修回日期:2014-08-08 出版日期:2014-12-15 发布日期:2019-06-14
  • 通讯作者: 孟丽亚 E-mail:mly0706@sina.com
  • 基金资助:
    山东大学第二医院青年基金/种子基金

Fractionated CO2 laser combined with 308-nm excimer laser for the treatment of stable vitiligo: an observational clinical study

  • Received:2014-01-13 Revised:2014-08-08 Online:2014-12-15 Published:2019-06-14

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摘要： 目的 观察CO2点阵激光联合308 nm准分子激光治疗稳定期白癜风的疗效和安全性。 方法 49例稳定期白癜风患者109处皮损，每一处白斑沿最长直径平均分成两半，一半为治疗组，先进行点阵激光治疗，15 ~ 20 min后，整个白斑同时照射308 nm准分子激光；未行点阵激光的另一半为对照组。308 nm准分子激光每周照射2次，CO2点阵激光每2周1次，连续治疗观察12周，治疗结束3 d后评价疗效。 结果 治疗组与对照组总有效率分别为92.7％（101/109）和77.1%（84/109）。治疗组与对照组显效率在面颈部分别为85.4%（35/41）和65.8%（27/41）（χ2 = 4.23，P < 0.05），躯干部分别为70.6%（24/34）和41.2%（14/34）（χ2 = 7.27，P < 0.01），四肢部位分别为64.0%（16/25）和36.0%（9/25）（χ2 = 3.92，P < 0.05），手背部5/9和1/9（χ2 = 4.00，P < 0.05），差异均有统计学意义。治疗组与对照组治疗次数（以308 nm准分子激光治疗次数计算）比较：面颈部分别为（7.24 ± 1.23）次和（10.81 ± 2.01）次（t = 9.70，P < 0.05），躯干部分别为（15.10 ± 2.47）次和（18.95 ± 3.45）次（t = 5.29，P < 0.05），四肢部位分别为（17.37 ± 3.84）次和（21.06 ± 4.23）次（t = 3.23，P < 0.05），差异均有统计学意义。所有患者在治疗过程中均未出现严重不良反应。 结论 CO2点阵激光联合308 nm准分子激光治疗白癜风有效而且安全。

关键词: 白癜风, 点阵激光, 疗效

Abstract: Meng Liya*, Wang Yifei, Zhang Chunmin. *Department of Dermatology, Second Hospital of Shandong University, Jinan 250033, China Corresponding author: Meng Liya, Email: mly0706@sina.com 【Abstract】 Objective To evaluate the efficacy and safety of fractionated CO2 laser combined with 308-nm excimer laser for the treatment of stable vitiligo. Methods Forty-nine patients with 109 lesions of stable vitiligo were enrolled in this clinical trial. Each of these lesions was equally divided into 2 parts along the longest diameter, which were then assigned into the treatment group and control group respectively. The treatment group were treated with fractionated CO2 laser radiation for 15 － 20 minutes once every two weeks combined with 308-nm excimer laser radiation twice weekly. The control group were only treated with 308-nm excimer laser radiation twice weekly. Efficacy was evaluated on day 3 after 12 consecutive weeks of treatment. Results After the treatment, the total response rate in the treatment group and control group was 92.7% （101/109） and 77.1% （84/109） respectively. The marked response rate in the treatment group and control group was 85.4% （35/41） and 65.8% （27/41） respectively for lesions on the face and neck （χ2 = 4.23, P < 0.05）, 70.6% （24/34） and 41.2% （14/34） respectively for lesions on the trunk （χ2 = 7.27, P < 0.01）, 64.0% （16/25） and 36.0% （9/25） respectively for lesions on the extremities （χ2 = 3.92, P < 0.05）, 5/9 and 1/9 respectively for lesions on the dorsal hands （χ2 = 4.00, P < 0.05）. The number of sessions of 308-nm excimer laser therapy required for the marked response of vitiligo in the treatment group and control group was 7.24 ± 1.23 and 10.81 ± 2.01 respectively for lesions on the face and neck （t = 9.70, P < 0.05）, 15.10 ± 2.47 and 18.95 ± 3.45 respectively for lesions on the trunk （t = 5.29, P < 0.05）, 17.37 ± 3.84 and 21.06 ± 4.23 respectively for lesions on the extremities （t = 3.23, P < 0.05）. No severe adverse reactions were observed in any of the patients during the treatment. Conclusion Fractionated CO2 laser combined with 308-nm excimer laser is effective and safe in treating stable vitiligo.

Key words: Vitiligo, Fractional laser, Efficacy