中华皮肤科杂志 ›› 2014, Vol. 47 ›› Issue (11): 810-811.

• 研究报道 • 上一篇    下一篇

青鹏软膏维持治疗对局限性湿疹预后的影响

路雪艳1,黄二顺1,谭燕红1,李邻峰2   

  1. 1. 北京大学第三医院
    2. 首都医科大学附属北京友谊医院皮肤科
  • 收稿日期:2014-02-12 修回日期:2014-04-13 出版日期:2014-11-15 发布日期:2014-11-01
  • 通讯作者: 李邻峰 E-mail:zoonli@sina.com

Effect of maintenance treatment with Qingpeng ointment on the prognosis of localized eczema

  • Received:2014-02-12 Revised:2014-04-13 Online:2014-11-15 Published:2014-11-01

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摘要： 目的 探讨外用青鹏软膏维持治疗对局限性湿疹复发情况的影响及其安全性。 方法 197例局限性湿疹患者，外用卤米松乳膏治疗。临床痊愈的患者随机分两组，分别外用青鹏软膏（青鹏组）或维生素E乳膏（润肤霜组）维持治疗，共2周。停药后观察8周，记录复发情况。 结果 137例患者进入维持治疗，青鹏组69例，润肤霜组68例。停药8周后，青鹏组复发率19.7%，润肤霜组37.31%，两组差异有统计学意义（χ2 = 5.06，P < 0.05）。青鹏组缓解时间（43.92 ± 15.70 d）长于润肤霜组（32.60 ± 14.40 d），两组比较，t = 2.23，P < 0.05。维持治疗期间，青鹏组不良反应发生率为1.45%，润肤霜组未见不良反应。 结论 外用青鹏软膏维持治疗局限性湿疹，有一定的延缓湿疹复发的作用，且安全性较好。

关键词: 湿疹, 维持治疗, 青鹏软膏

Abstract: Lu Xueyan, Huang Ershun, Tan Yanhong, Li Linfeng. Department of Dermatology, Peking University Third Hospital, Beijing 100191, China Corresponding author: Li Linfeng, Email: zoonli@tom.com 【Abstract】 Objective To evaluate the efficacy and safety of maintenance treatment with Qingpeng ointment in the prevention of recurrence of localized eczema. Methods Totally, 197 patients with localized eczema were topically treated with halometasone cream for 2 － 4 weeks. The patients who achieved clinical cure were then randomly classified into two groups to receive maintenance treatment with Qingpeng ointment （Qingpeng group, n = 69） or vitamin E-containing cream （emollient group, n = 68）. Patients were followed up for 8 weeks for the detection of recurrence after the discontinuation of maintenance treatment. Results During the follow up, the recurrence rate in the Qingpeng group was significantly lower than that in the emollient group（19.70% vs. 37.31%, χ2 = 5.06, P <0.05）. Significant differences were also observed in the duration of remission between the Qingpeng group and emollient group （（43.92 ± 15.70） vs. （32.60 ± 14.40） days, t = 2.23, P < 0.05）. The incidence rate of adverse reactions was 1.45% in the Qingpeng group during the maintenance treatment, and no adverse reactions were observed in the emollient group. Conclusion The maintenance treatment with Qingpeng ointment can delay the recurrence of localized eczema to some extent with a favorable safety.

Key words: Eczema, Maintenance treatment, Qingpeng ointment