中华皮肤科杂志

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银屑病患者皮损中CD147、亲环素A和亲环素B的表达

陈翔, 李娟, 粟娟, 吴轶西, 常静, 彭胜, 匡叶红   

  1. 中南大学湘雅医院皮肤科, 长沙, 410008
  • 收稿日期:2006-11-17 出版日期:2007-10-15 发布日期:2007-10-15
  • 基金资助:
    国家自然科学基金(30571682);霍英东高校青年教师基金(91040);教育部优秀青年教师资助计划(2003-189);教育部新世纪优秀人才支持计划(2006)基金;湖南省杰出青年基金(2006);湘雅医院“百万人才战略工程”基金(2006)资助

Expression of CD147,cyclophilin A and cyclophilin B in psoriatic lesions

CHEN Xiang, LI Juan, SU Juan, WU Yi-xi, CHANG Jing, PENG Sheng, KUANG Ye-hong   

  1. Department of Dermatology, Xiangya Hospital, Central South University, Changsha 410008, China
  • Received:2006-11-17 Online:2007-10-15 Published:2007-10-15

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摘要： 目的 检测CD147、亲环素A和亲环素B在正常人皮肤和银屑病皮损中的表达,探讨它们在银屑病发病机制中的作用。方法 用免疫组化法半定量检测银屑病皮损和正常人皮肤中CD147、亲环素A和亲环素B的表达,用免疫反应强度分布指数(IRIDI)表示。结果 银屑病各组角质形成细胞中CD147和亲环素A的IRIDI均显著高于正常对照组(P值均<0.05)。脓疱性银屑病组角质形成细胞、T细胞和中性粒细胞中CD147和亲环素A的IRIDI均显著高于进展期寻常性银屑病组(P值均<0.05)。寻常性银屑病组角质形成细胞中CD147和亲环素A的IRIDI差异无统计学意义(P值均>0.05),进展期寻常性银屑病组T细胞和中性粒细胞中CD147和亲环素A的IRIDI均显著高于静止期寻常性银屑病组(P值均<0.05)。脓疱性银屑病组T细胞中亲环素B的IRIDI显著高于进展期寻常性银屑病组(P<0.05),进展期寻常性银屑病组T细胞中亲环素B的IRIDI显著高于静止期寻常性银屑病组(P<0.05)。所有组间角质形成细胞及银屑病组间中性粒细胞中亲环素B的IRIDI差异无统计学意义(P值均>0.05)。结论 CD147、亲环素A和亲环素B可能在银屑病的发生发展中起作用。

关键词: 银屑病, 抗原, CD147, 亲环素类, T淋巴细胞, 中性白细胞

Abstract: Objective To study the expression and pathologic significance of CD147,cyclophilin A (CyPA)and cyclophilin B(CyPB)in psoriatic lesions.Methods Immunohistochemical method was applied to detect the expression of CD147,CyPA and CyPB in skin specimens of 15 patients with psoriasis pustulosa(PP),20 patients with progressive psoriasis vulgaris(PPV),and 20 patients with inactive psori-asis vulgaris(IPV).Immunoreactivity intensity distribution index(IRIDI)was calculated to assess the expression intensity of CD147,CyPA and CyPB.Results CD147,CyPA and CyPB were detected in all specimens.The IRIDI scores of CD147 and CyPA were significantly higher in keratinocytes of psoriatic lesions than in those of the control specimens(all P<0.05),in keratinocytes,T cells and neutrophils of PP lesions than in those of PPV lesions(all P<0.05),in T lymphocytes and neutrophils of PPV lesions than in those of IPV lesions(all P<0.05).There was no significant difference in the keratinocytes of PPV and IPV lesions(P>0.05).The IRIDI score of CyPB in T lymphocytes of PP lesions was significantly elevated than that in PPV lesions,which was in turn higher than that in IPV lesions(all P<0.05).However,no significant difference was found in the IRIDI score of CyPB among the keratinocytes of all groups,or among the neutrophils of the three psoriatic groups(all P>0.05).Conclusion CD147,CyPA and CyPB may play a role in the occurrence and development of psoriasis.

Key words: Psoriasis, Antigens, CD147, Cyclophilins, T-lymphocytes, Neutrophils