关键词: 银屑病, 成纤维细胞生长因子1, 丝裂原活化蛋白激酶1, 抗原，CD34

Abstract: JIAO Jian*, ZHANG Chun-hong, L?譈 Shi-feng. *Derpartment of Dermatology, Qilu Hospital of Shandong University, Jinan 250012, China Corresponding author: ZHANG Chun-hong, Email: aliu133@163.com 【Abstract】 Objective To estimate the relationship of fibroblast growth factor-1 （FGF-1）, mitogen activated protein kinase-1（MAPK-1） and CD34 expressions with clinicopathological findings in lesions of psoriasis vulgaris. Methods Skin specimens were collected from 30 patients with psoriasis vulgaris, whose general information and clinical findings were recorded. The protein expressions of FGF-1, MAPK-1 and CD34 in these specimens were detected by tissue chip technology and immunohistochemistry, and the mRNA expression of FGF-1 by reverse transcription-PCR. The correlations of FGF-1 protein expression with patients′ gender, age, clinical stage, psoriasis area and severity index （PASI） score, angiogenesis and abnormal epidermal proliferation were statistically analyzed. Results The protein and mRNA expressions of FGF-1 were significantly higher in the lesions than in the control skin （both P < 0.05）. The protein expressions of CD34 and MAPK-1 were significantly increased, and positively associated with the protein expression of FGF-1 in psoriatic lesions. The up-regulation of FGF-1 protein was unrelated to the age or gender of patients, but associated with clinical stage and PASI score. The proportion of patients with increased FGF-1 expression was significantly larger in patients at active stage and with high PSAI score than in those at quiescent stage and with low PSAI score （P < 0.05）. Conclusions In psoriasis vulgaris,FGF-1 may participate in the abnormal epidermal proliferation and vascular dysplasia in dermal papilla, and the upregulation of FGF-1 appears to be associated with the progression of disease and aggravation of lesions. 【Key words】 Psoriasis; Fibroblast growth factor 1; Mitogen-activated protein kinase 1; Antigens, CD34

Key words: FGF-1, MAPK-1