空间转录组学及其在皮肤疾病中的应用

doi:10.35541/cjd.20220429

中华皮肤科杂志 ›› 2025, e20220429.doi: 10.35541/cjd.20220429

空间转录组学及其在皮肤疾病中的应用

魏亚鹿,沈征宇

上海交通大学医学院附属第九人民医院皮肤科，上海 200011

收稿日期:2022-06-15 修回日期:2023-09-30 发布日期:2025-02-10
通讯作者: 沈征宇 E-mail:neuronszy@sina.com
基金资助:
上海交通大学医学院附属第九人民医院交叉基金（JYJC201901）

Spatial transcriptomics and its application in dermatology

Wei Yalu, Shen Zhengyu

Department of Dermatology, Shanghai Ninth People′s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China

Received:2022-06-15 Revised:2023-09-30 Published:2025-02-10
Contact: Shen Zhengyu E-mail:neuronszy@sina.com
Supported by:
Cross-disciplinary Research Fund of Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine（JYJC201901）

摘要/Abstract

摘要： 【摘要】细胞的基因表达具有时空特异性，其中的空间位置信息对于研究组织生理功能和病理变化有重要意义。近年新兴的空间转录组学技术可以系统地测量组织中所有或大多数基因的表达水平，保留细胞的空间位置信息，有利于研究细胞间通讯及细胞与组织、器官间的作用等，在多个领域的研究中展现出独有的优势。本文在介绍空间转录组技术的基础上归纳了其在一些皮肤疾病研究中的应用与价值，并针对目前该技术的发展状况提出应用前景。

关键词: 转录组, 空间转录组, 黑色素瘤, 炎症性皮肤疾病

Abstract: 【Abstract】 The intracellular gene expression is characterized by spatiotemporal specificity, and spatial location information is critical for the research of physiological function and pathological changes of tissues. The emerging spatial transcriptomic technologies in recent years can systematically determine the expression of all or most genes in tissues, retain the spatial location information of cells, which facilitates research on cell-cell communication and interactions between cells and tissues/organs, demonstrating unique advantages in various fields of study. Based on an introduction to spatial transcriptomics technology, this review summarizes its applications and value in the research of some skin diseases, and proposes future prospects according to the current development status of the technology.

Key words: Transcriptome, Spatial transcriptomics, Melanoma, Inflammatory skin disease

魏亚鹿沈征宇. 空间转录组学及其在皮肤疾病中的应用[J]. 中华皮肤科杂志, 2025,e20220429. doi:10.35541/cjd.20220429

Wei Yalu, Shen Zhengyu. Spatial transcriptomics and its application in dermatology[J]. Chinese Journal of Dermatology,2025,e20220429. doi:10.35541/cjd.20220429

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空间转录组学及其在皮肤疾病中的应用

Spatial transcriptomics and its application in dermatology

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