中华皮肤科杂志 ›› 2022, e20220173.doi: 10.35541/cjd.20220173

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昼夜节律与黑素瘤相关性的研究进展

陈雁雁    张翰林    刘莉萍    李遇梅   

  1. 江苏大学附属医院皮肤科  江苏大学再生医学研究院,镇江  212001
  • 收稿日期:2022-03-15 修回日期:2022-05-16 发布日期:2022-07-04
  • 通讯作者: 李遇梅 E-mail:yumeili@ujs.edu.cn
  • 基金资助:
    国家自然科学基金(82103766)

Correlations between circadian rhythm and melanoma

Chen Yanyan, Zhang Hanlin, Liu Liping, Li Yumei   

  1. Department of Dermatology, Affiliated Hospital of Jiangsu University, Jiangsu University Institute for Regenerative Medicine, Zhenjiang 212001, Jiangsu, China
  • Received:2022-03-15 Revised:2022-05-16 Published:2022-07-04
  • Contact: Li Yumei E-mail:yumeili@ujs.edu.cn
  • Supported by:
    National Natural Science Foundation of China(82103766)

摘要: 【摘要】 黑素瘤的病因和发病机制尚不完全明确。研究表明,昼夜节律紊乱可重构黑素瘤免疫微环境,影响DNA修复及黑素合成等过程,可能是黑素瘤发生发展的重要环节。此外,生物钟基因的突变亦能增加黑素瘤的遗传易感性。该文综述昼夜节律参与黑素瘤发生发展的相关机制及其在黑素瘤治疗中的新进展,为黑素瘤的预防和治疗提供新的视角。

关键词: 黑色素瘤, 昼夜节律, 时间疗法

Abstract: 【Abstract】 The etiology and pathogenesis of melanoma are not fully elucidated. Recent studies have shown that circadian rhythm disruption can reconstruct the immune microenvironment of melanoma, and affect DNA repair, melanin synthesis and other processes, and may be an important step in the occurrence and development of melanoma. In addition, mutations in circadian clock genes can also increase the genetic susceptibility to melanoma. This review focuses on mechanisms underlying the regulation of circadian rhythm in the occurrence and development of melanoma, and new progress in melanoma treatment, providing a completely new perspective for the prevention and treatment of melanoma.

Key words: Melanoma, Circadian rhythm, Chronotherapy

引用本文

陈雁雁 张翰林 刘莉萍 李遇梅. 昼夜节律与黑素瘤相关性的研究进展[J]. 中华皮肤科杂志, 2022,e20220173. doi:10.35541/cjd.20220173

Chen Yanyan, Zhang Hanlin, Liu Liping, Li Yumei. Correlations between circadian rhythm and melanoma [J]. Chinese Journal of Dermatology,2022,e20220173. doi:10.35541/cjd.20220173