中华皮肤科杂志 ›› 2010, Vol. 43 ›› Issue (9): 649-650.

• 短篇论著 • 上一篇    下一篇

PI3K-Akt在皮肤鳞状细胞癌组织中的表达

朱里1,陈思远2,林能兴3,吴艳2,黄长征3,刘厚君1,涂亚庭1   

  1. 1. 武汉华中科技大学同济医学院附属协和医院皮肤科
    2.
    3. 华中科技大学同济医学院附属协和医院皮肤科
  • 收稿日期:2010-01-04 修回日期:2010-02-06 发布日期:2010-09-10
  • 通讯作者: 陈思远 E-mail:siyuanchen_cn@hotmail.com

Expression of PI3K-Akt in the tissue of cutaneous squamous cell carcinoma

  • Received:2010-01-04 Revised:2010-02-06 Published:2010-09-10

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摘要：

【摘 要】 目的 检测皮肤鳞状细胞癌(SCC)组织中磷脂酰肌3-激酶(PI3K)及其下游分子蛋白激酶B(AKT)蛋白的表达，探讨其在SCC增殖及癌变中的作。 方法 采用免疫组织化学SP法检测41例SCC，11例正常皮肤组织石蜡标本中PI3K，AKT蛋白的表达。结果 SCC组织中PI3K，AKT蛋白的阳性表达率(65.85%和73.17%)明显高于正常皮肤(18.18%和0%，P<0.05)。SCC组织中PI3K的阳性表达率与AKT的阳性表达率呈正相关(r=0.418,P<0.05)。结论 PI3K-AKT通路可能在SCC的发生过程中起重要作用。

关键词: 皮肤肿瘤, 鳞状细胞癌, PI3K, AKT

Abstract:

Abstract: Objective To detect the expression of PI3K and AKT in cutaneous squamous cell carcinoma (SCC) tissue. Methods The expressions of PI3K and AKT were detected in 41 cases of SCC tissue and 11 cases of normal skin tissue by immunohistochemical SP. Results The positive expression rates of PI3K and AKT in SCC were higher than those in normal skin tissue ( P <0. 05). The expression of PI3K in SCC tissue was postively correlated with that of AKT (r = 0. 418, P <0. 05). Conclusion It is suggested that expression of PI3K and AKT may be closely correlated with generation of SCC.

Key words: cutaneous neop lasm, squamous cell carcinoma, PI3K, AKT