中华皮肤科杂志 ›› 2007, Vol. 40 ›› Issue (2): 107-109.

• 论著 • 上一篇    下一篇

弥漫性色素沉着伴点状色素减退三例:一种新的色素性疾病?

姜祎群, 曾学思, 韩永智, 徐秀莲, 孙建方   

  1. 中国医学科学院、中国协和医科大学皮肤病研究所 南京 210042
  • 收稿日期:2006-01-24 发布日期:2007-02-15

Diffuse hyperpigmentation with guttate depigmented macules:a new entity of pigmentary disorder?

JIANG Yi-qun, ZENG Xue-si, HAN Yong-zhi, XU Xiu-lian, SUN Jian-fang   

  1. Institute of Dermatology, Chinese Academy of Medical Sciences & Peking Union Medical College, Nanjing 210042, China
  • Received:2006-01-24 Published:2007-02-15

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摘要： 报告3例特殊表现的色素异常性疾病.患者2男1女,年龄分别是13,15和11岁,自幼全身皮肤弥漫发黑,略呈铅灰色外观,同时在黑变的基础上出现密集点状白斑,随年龄增长逐渐明显.均无家族史.病理显示表皮基底层轻微黑变、灶性空泡化和真皮浅层色素失禁.患者的症状与目前报道的所有色素性疾病不能吻合,故作为一种新的单独的疾病加以报道.

关键词: 色素异常, 色素沉着, 色素减退

Abstract: Three cases,characterized by widespread depigmented macules 2-4 mm in diameter over an uniformly lead-gray appearance of skin,are reported here.The patients (2 boys and l girl,aged 13,15,and 11 years,respectively) all had an early childhood onset,a negative family history,and a slowly progressive course with no tendency for spontaneous involution.Biopsy of the depigmented macules revealed slight basal hyperpigmentation of the epidermis and pigment incontinence in the upper dennis.In an extensive review of the literature,no similar cases were found.Therefore,it may be considered as a new entity of pigmentary disorder.

Key words: Pigmentation disorders, Hyperpigmentation, Hypopigmentation