中华皮肤科杂志 ›› 2005, Vol. 38 ›› Issue (6): 342-344.

• 论著 • 上一篇    下一篇

自体血清皮肤试验阳性与阴性慢性荨麻疹患者临床特点分析

孙蔚凌, 毕志刚   

  1. 南京医科大学第一附属医院皮肤科 210029
  • 收稿日期:2004-08-10 出版日期:2005-06-15 发布日期:2005-06-15
  • 通讯作者: 毕志刚,E-mail:eltonbi@21cn.com E-mail:eltonbi@21cn.com

Clinical Features of Chronic Urticaria in Patients with Positive and Negative Autologous Serum Skin Test

SUN Wei-ling, BI Zhi-gang   

  1. Department of Dermatology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China
  • Received:2004-08-10 Online:2005-06-15 Published:2005-06-15

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摘要： 目的 探讨自体血清皮肤试验阳性的慢性荨麻疹患者的临床特点。方法 从82例慢性荨麻疹患者中筛选出29例自体血清皮肤试验阳性患者,对其症状体征及病史等进行分析,并用放免法测定其血清中的抗甲状腺球蛋白抗体(TG-AB)和抗甲状腺微粒体抗体(TM-AB),与自体血清皮肤试验阴性的慢性荨麻疹患者进行对比。结果 自体血清皮肤试验阳性与阴性的慢性荨麻疹患者在年龄分布、病程上差异无统计学意义(P>0.05)。两组患者症状体征评分比较,自体血清皮肤试验阳性患者皮疹发作时风团较大(P<0.05),数量较多(P<0.01),每次发作持续时间较长(P<0.05),瘙痒更剧烈(P<0.05);但风团外观较红,隆起不明显(P<0.01);而两组患者的皮疹发作频次差异无统计学意义(P>0.05)。自体血清皮肤试验阳性的慢性荨麻疹患者伴发血管神经性水肿及系统症状的比例较高,伴随其他自身免疫相关疾病和甲状腺抗体阳性的比例也明显高于自体血清皮肤试验阴性患者(P<0.05)。结论 自体血清皮肤试验阳性的慢性荨麻疹多表现为较严重的慢性荨麻疹。

关键词: 皮内试验, 自身免疫疾病, 荨麻疹

Abstract: Objective To determine whether there are differences of clinical features or severity of chronic idiopathic urticaria(CIU) between patien ts with positive(ASST+)and negative (ASST-)autologous serum skin test. Methods The clinical features of the patients with ASST+ were evaluated and compared with those of the patients with ASST-.Anti-thyroid antibodies in serum were det ected by radioimmunoassay. Results There were no significant difference of age distribution and course of the disease between the ASST+ and ASST-urticaria patients(both P>0.05).ASST+ patients had larger wheals(P<0.05),more wheals(P<0.01),longer periods of individual wheals(P<0.05),higheritch scores(P<0.01),more systemic symptoms(P<0.01)and higher positive rate of anti-thyroi d antibodies than ASST-patients did.ASST+ patients also had the history of autoimmune conditions more often than ASST-patients did(P<0.05). Conclusion The positive autologous serum skin test indicates a subset of patients with much severe CIU.

Key words: Urticaria, Intradermal tests, Autoimmune diseases